STRUCTURAL FUNCTIONAL RELATIONSHIPS IN DIABETIC NEPHROPATHY

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 该协议有两个主要目的。首先，我们正在研究糖尿病肾病的结构-功能关系，使用定量光和电子显微镜形态计量学来确定微量蛋白尿、蛋白尿、高血压和GFR下降的结构底物。其次，我们正在研究胰腺移植在成功移植后五年、十年和十五年对糖尿病肾病已建立的病变的影响。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This protocol has two major purposes. First, we are examining structural-functional relationships in diabetic nephropathy using quantitative light and electron microscopic morphometry to determine the structural substrates for microalbuminuria, proteinuria, hypertension and declining GFR. Secondly, we are examining the effects of pancreas transplant on the established lesions of diabetic nephropathy at five, ten, and fifteen year intervals after successful transplantation.