PET STUDIES OF SLEEP DEPRIVATION

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 使用PET评估睡眠剥夺对大脑多巴胺能功能的影响，并将其与认知和行为影响联系起来。 我们假设睡眠剥夺会上调多巴胺转运蛋白（DAT）。 目的：利用功能磁共振成像（fMRI）技术研究睡眠剥夺被试在言语工作记忆和视觉空间注意过程中的血氧水平依赖性（BOLD）反应。 我们假设，在睡眠剥夺期间，前额叶和顶叶皮层的激活将显着减少，这些异常将与受损的任务表现。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. To use PET to assess the effects of sleep deprivation in brain dopaminergic function and to relate this to its cognitive and behavioral effects. We hypothesize that sleep deprivation will upregulate the dopamine transporter (DAT). To use fMRI to investigate the blood oxygenation level dependent (BOLD) response during verbal working memory and visuospatial attention in sleep deprived subjects. We hypothesize that during sleep deprivation, the activations in the prefrontal and parietal cortices will be significantly decreased and these abnormalities would correlate impaired task performance.