ROLE OF ION FLUXES DURING REGENERATION

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目及 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 再生是医学的一个关键目标，因为它与损伤，出生缺陷，癌症和衰老的治疗有关。利用各种分子工具，我们正在研究某些动物（Planarian扁形虫和爪蟾蝌蚪）再生中枢神经系统细胞的能力。我们已经发现，伤口细胞迅速上调特定离子通道和离子泵的表达，并且它们的生物电活性对于神经、肌肉和其他细胞类型的再生至关重要。理解伤口电流的生物物理特性的能力对于未来的生物医学方法（旨在诱导人类受损组织的再生）至关重要，我们依赖于BRC用于表征伤口电流以及细胞募集和组织再生的生物电作用所需的技术。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Regeneration is a key goal of medicine, as it bears on therapies for injuries, birth defects, cancer, and aging. Using a variety of molecular tools, we are investigating the ability of certain animals (planarian flatworms and Xenopus tadpoles) to regenerate central nervous system cells. We have discovered that wound cells rapidly up-regulate the expression of specific ion channels and ion pumps, and that their bioelectric activity is crucial for the regeneration of nerve, muscle, and other cell types. The ability to understand the biophysical properties of the wound currents are crucial to future biomedical approaches (aimed to induce regeneration of damaged tissues in humans), and we depend on the BRC for the technology necessary to characterize wound currents and the bioelectrical action of cell recruitment and tissue regeneration.