ORAL MUCOSAL IMMUNITY IN VULNERABLE HIV INFECTED POPULATIONS

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 自1980年代首次描述艾滋病毒/艾滋病感染以来，艾滋病毒/艾滋病口腔并发症的频率发生了变化，包括口腔念珠菌病、卡波西氏肉瘤、口疮、口腔毛状白斑、巨细胞病毒、单纯疱疹病毒、坏死性溃疡性牙周炎和口腔疣。人β防御素通过提供直接的抗微生物活性和通过调节与适应性免疫系统的细胞的串扰，在粘膜防御中发挥核心作用。该项目旨在通过蛋白质组学、基因组学和蛋白质结构/功能方法确定HIV感染后口腔并发症的易感性，并重点研究口腔粘膜和人类β防御素的先天免疫。遗传分析将集中在先天免疫基因与艾滋病毒感染者口腔并发症易感性之间的关联，以及β防御素基因拷贝数变异与对CCR5和CXCR4共同受体在艾滋病毒细胞进入中的易感性之间的关联。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The frequency of oral complications of HIV/AIDS; including oral candidiasis, Kaposi's sarcoma, aphthous ulcers, oral hairy leukoplakia, CMV, HSV, necrotizing ulcerative periodontitis, and oral warts have changed since the initial description of the infection in the 1980s. Human beta defensins play a central role in mucosal defenses by providing direct anti-microbial activity and by mediating cross-talk with cells of the adaptive immune system. This project aims to determine susceptibility to oral complications following HIV infection, by using proteomics, genomics, and protein structure/function approaches and to focus on innate immunity in the oral mucosa and human beta defensins. Genetic analyses will focus on the association between innate immunity genes and susceptibility to development of oral complications in HIV-infected individuals, and the association between copy number variants in beta defensin genes and susceptibility to CCR5 vs. CXCR4 co-receptor use in cellular entry of HIV.