EX VIVO MULTIMODAL SPECTROSCOPY OF BREAST CANCER

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 我们已经开发了MMS仪器，结合拉曼，漫反射和固有荧光光谱模式。我们以前的结果从两个临床仪器，提供信息的拉曼和漫反射和固有荧光光谱的组合，分别使我们能够诊断正常，纤维囊性变化，纤维腺瘤和浸润性导管癌病变的高灵敏度和特异性。在新的临床离体研究中，将通过多模式前视探头从新鲜切除的乳腺组织的相同部位收集所有三种模式的光谱信息。本研究将在部分和整个乳房切除术期间切除后半小时内在University Hospitals-Case医学中心的病理室进行。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We have developed the MMS instrument that combines Raman, diffuse reflectance and intrinsic fluorescence spectroscopy modalities. Our previous results obtained from two clinical instruments that provide information on Raman and combination of diffuse reflectance and intrinsic fluorescence spectroscopies, respectively, have allowed us to diagnose normal, fibrocystic change, fibroadenoma and infiltrating ductal carcinoma lesions with high sensitivity and specificity. In the new clinical ex vivo study spectral information from all three modalities will be collected from the same site of the freshly excised breast tissue via multimodal front-viewing probe. This study will be conducted in the pathology suite in the University Hospitals-Case medical center within half an hour of excision during partial and whole mastectomy.