STU1P FUNCTION IN YEAST MITOSIS THROUGH ANALYSIS OF PROTEIN-PROTEIN INTERACTIONS

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 酿酒酵母Stu1p蛋白在有丝分裂纺锤体功能中起重要作用。它是有丝分裂纺锤体形成和维持所必需的。Stu1p是位于有丝分裂纺锤体中区的蛋白质网络的一部分。我们试图了解纺锤体中区网络中的蛋白质-蛋白质相互作用，以更好地理解有丝分裂纺锤体的建立和维持。由于Stu1p是这个网络的重要成员，我们有兴趣了解它是否与其他中区蛋白相互作用，以及这些相互作用是否对Stu1p的功能是必要的。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The Saccharomyces cerevisiae protein Stu1p has an essential role in mitotic spindle function. It is necessary for mitotic spindle formation and maintenance. Stu1p is part of a network of proteins localized at the mitotic spindle midzone. We are attempting to understand the protein-protein interactions within this spindle midzone network, to better understand the establishment and maintenance of the mitotic spindle. Since Stu1p is an essential member of this network, we are interested in understanding whether it interacts with other midzone proteins, and whether these interactions are necessary for Stu1p function.