Analytical Core

9.1.1分析核心共享服务 分析核心共享服务(ACSS)的总体使命是为癌症中心的投资者提供 集中资源和专业知识执行分析化学分析和药代动力学 药效学数据分析和解释。 具体地说，分析核心共享服务有以下目标： ？为开发和实施基于层析的生物分析方法提供支持 癌症治疗和预防药物、营养素、致癌物和内源性生物化学物质的质量鉴定 在生物标本中； ？在癌症治疗和预防药物、营养素、致癌物、 临床和临床前标本中的内源性生物化学物质； ？提供支持，为收集的样品制定适当的样品处理和储存条件 生物分析检测； ？在制定药代动力学样本采集计划和药物动力学和 药效学数据分析与解释。 这些服务可以评估药物/营养/致癌物质的暴露和处置情况。服务 由ACSS提供，还支持测量内源性化学物质作为替代癌症风险生物标志物和 药效学终点。这些研究路线对目前正在进行的许多项目都是必不可少的 在亚利桑那州癌症中心进行，特别是在强调药物开发和 癌症预防研究。

9.1.1 ANALYTICAL CORE SHARED SERVICE The overall mission of the Analytical Core Shared Service (ACSS) is to provide Cancer Center invesfigators with centralized resources and expertise in performing analytical chemistry assays and pharmacokinefic and pharmacodynamic data analysis and interpretation. Specifically, the Analytical Core Shared Service has the following aims: ¿To provide support in developing and implementing chromatography-based bioanalytical assays for quarifification of cancer therapeufic and preventive agents, nutrients, carcinogens, and endogenous biochemicals in biological specimens; ¿To provide support in quanfitafive analysis of cancer therapeutic and preventive agents, nutrients, carcinogens, and endogenous biochemicals in clinical and preclinical specimens; ¿To provide support in developing proper sample handling and storage conditions for specimens collected for bioanalytical assays; ¿To provide support in designing pharmacokinetic sample collection schedules and pharmacokinefic and pharmacodynamic data analysis and interpretafion. These services allow for the assessment of drug/nutrient/carcinogen exposure and disposition. Services provided by ACSS also support measurement of endogenous chemicals as surrogate cancer-risk biomarkers and pharmacodynamic endpoints. These lines of research have been essential to many projects currently being carried out at the Arizona Cancer Center, especially in programs with an emphasis in drug development and cancer prevenfion research.