Training Program in Systemic Autoimmunity

描述（由申请人提供）：这是哈佛医学院（HMS）贝斯以色列医学女执事医学中心（BIDMC）系统性自身免疫培训计划的新提案。它要求每年支助两名受训人员，他们将在该方案中至少呆两年。受训人员将通过以下途径之一进入该计划：寻求风湿病学或肾脏病学培训的医生，进入其他临床奖学金计划的医生，包括神经病学和皮肤病学，在与系统性自身免疫性疾病相关的领域完成临床培训的医生以及具有免疫学，生物化学和细胞/分子生物学背景的博士。选择的主要标准将是致力于系统性自身免疫性疾病研究的证据。通过这项培训，医生将发展免疫学和生物学/生物化学方面的技能，而博士将熟悉与系统性自身免疫性疾病研究相关的临床问题。研究活动将涵盖人类和动物T细胞、B细胞、NKT细胞、巨噬细胞、肥大细胞、共刺激、免疫细胞信号传导、免疫耐受、细胞因子表达和功能的控制、区域免疫学和生物学（肾脏、皮肤和神经系统）的相关方面、人类遗传学、免疫缺陷、补体和免疫调节。主要的教学方法将包括在一位资深科学家的密切监督下亲自参与一项基础研究计划。此外，在研究研讨会、期刊俱乐部、国家和国际会议上的研究报告和赠款写作方面，还制定了一个结构化的教学课程方案。培训的主要设施在BIDMC和HMS附属机构。毕业学员将能够计划，寻求资金，并执行系统性自身免疫性疾病的前沿研究，并将得到适当的工具来开发新的诊断和治疗方法。该计划将培养系统性自身免疫性疾病研究方面的顶尖研究人员，他们将领导学术中心的基础和临床研究，以促进对患有这些疾病的人的护理。

DESCRIPTION (provided by applicant): This is a new proposal of a training program in systemic autoimmunity at the Beth Israel Medical Deaconess Medical Center (BIDMC), Harvard Medical School (HMS). It requests support for two trainees each year who will spend at least two years in the program. Trainees will enter the program through one of the following tracks: Physicians who seek training in rheumatology or nephrology, physicians who enter other clinical fellowship programs including neurology and dermatology, physicians who have completed clinical training in a field relevant to systemic autoimmune diseases and PhDs with background in immunology, biochemistry and cell/molecular biology. The major criterion for selection will be evidence of commitment to the study of systemic autoimmune diseases. Through this training physicians will develop skills in immunology and biology/biochemistry, whereas PhDs will become familiar with clinical issues pertinent to the study of systemic autoimmune diseases. Research activities will span studies in human and animal T cells, B cells, NKT cells, macrophages, mast cells, costimulation, immune cell signaling, immune tolerance, control of cytokine expression and function, pertinent aspects of regional immunology and biology (kidney, skin and nervous system), human genetics, immunodeficiency, complement and immunomodulation. The chief method of instruction will involve personal involvement in a program of basic research under the close supervision of a senior scientist. Moreover, a structured program of didactic courses in research seminars, journal clubs, research presentations in national and international meetings and grant writing is in place. The primary facilities for training are at BIDMC and HMS-affiliated institutions. Graduating trainees will be able to plan, seek funding, and execute cutting edge research in systemic autoimmune diseases and will be properly tooled to develop new diagnostics and therapeutics. This program will develop top notch researchers in the study of systemic autoimmune diseases who will lead basic and clinical research in academic centers to advance the care of people suffering from these diseases.