Neuroimaging Core

神经成像核心作为仪器、数据采集、处理和 支持项目1和2中进行的实验的分析。该核心将提供尖端技术 神经成像的进步和计算工具，这对优化数据处理非常重要。这个 这个核心的主任Thomas Liu博士也是加州大学圣迭戈分校功能磁学中心的主任 磁共振成像(FMRI)，因此，承载了加州大学洛杉矶分校现有的重要基础设施 这项提案的功能磁共振成像中心。此外，刘博士在灌注成像方面的专业知识将有助于提供 分析方法以确定不同组之间血液灌注量的普遍差异是否占主导地位 在内部感觉和线索反应任务中大胆的fMRI差异，将确保高质量 神经成像数据。这一核心的具体目标是： (1)利用加州大学圣迭戈分校fMRI中心开发的神经成像程序提供持续质量 控制正在进行的实验。 这一目标将帮助我们优化成像分析步骤，并实施明确的质量控制 与其他大规模功能磁共振研究的结果相似。 (2)提供核心计算基础设施，以标准化和优化神经影像管道。 这将有助于我们将为项目1获得的图像与项目2的图像进行比较，以更好地描绘 在整个成瘾周期中，内部感觉调节失调的程度。 (3)为所有与CIDIA有关的神经影像研究人员提供基本和高级培训 获取和分析。 这一目标主要侧重于将神经成像核心的教育和培训活动结合起来，以便 为了节省我们引进新研究人员的能力，保持神经成像领域的高水平专业知识 研究人员，并吸收文献中的新见解，以优化图像分析途径。 通过实现这些目标，核心将主要支持项目1和2，这将使其更容易和 比较不同项目的数据集更为合适。然而，我们也设想，这一核心将开始 为了探索未来动物神经成像的可能性，这可以在完全中心延伸的 这个最初的项目。

The Neuroimaging Core functions as a resource for instrumentation, data acquisition, processing, and analysis in support of the experiments conducted in Projects 1 and 2. This core will provide cutting edge neuroimaging advances and computational tools, which are important to optimize data processing. The director of this core, Dr. Thomas Liu, is also the Director of the UCSD Center for Functional Magnetic Resonance Imaging (fMRI) and, therefore, brings to bear the significant existing infrastructure of the UCSD Center for fMRI for this proposal. Moreover, Dr. Liu's expertise in perfusion imaging will help provide analysis approaches to determine whether general differences in blood perfusion across groups account for BOLD fMRI differences during the interoception and cue reactivity tasks, and will ensure high quality neuroimaging data. The specific aims of this core are: (1) To utilize neuroimaging procedures developed at the UCSD Center for fMRI to provide continued quality control of ongoing experiments. This aim will help us to optimize our imaging analyses steps and to have explicit quality control implemented similar to that of other large-scale fMRI studies. (2) To provide a core computational infrastructure to standardize and optimize the neuroimaging pipeline. This will help us to compare images obtained for Project 1 with those of Project 2 to better delineate the degree of dysregulated interoception across the addiction cycle. (3) To provide basic and advanced training for all CIDIA associated investigators for neuroimaging acquisition and analysis. This aim is focused primarily on combine educational and training activities in the Neuroimaging Core so as to economize our ability to bring in new investigators, maintain high level of expertise among neuroimaging investigators, and incorporate new insights from the literature to optimize the image analysis pathway. By accomplishing these aims, the core will primarily support Projects 1 and 2, which will make it easier and more appropriate to compare data sets across projects. However, we also envision that this core will begin to explore the possibility for future animal neuroimaging, which could be done in a full center extension of this initial project.