CONTE CENTER

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 这个项目有三项研究，利用了在孔特资助的前一个资助期产生的应激和控制非人类灵长类动物的队列。 研究1研究人员考察了早期压力对后续认知能力的影响，重点放在陈述性和非陈述性记忆功能上。 研究2研究人员观察了早期压力对情绪行为发展的影响，重点是恐惧和焦虑，以及大脑葡萄糖代谢的变化。 研究3的研究人员询问，早期的压力是否会导致可卡因自我管理的速度比对照组猴子更快，以及与对照组猴子相比，它们对灭绝的抵抗力是否更强。 这些研究使用结构和/或功能脑成像来澄清行为变化和大脑变化之间的关系，并将通过神经化学评估来澄清由于早期生活压力而导致的行为变化和脑化学之间的关系。 研究1和研究2使用相同的猴子群体。这既是对一种非常有价值的资源的有效利用，也是让我们能够比较同一动物在两个不同行为领域，即记忆和情绪方面的发现。在必要的情况下，一组完全不同的猴子被用于研究3。 猴子继续接受测试。其中几个已经安装了遥测植入物，并接受了PET研究。研究3猴子的训练即将完成。 这是孔蒂中心赠款资助的最后一年。这些动物正在被重新分配到一些项目中，这些项目将使我们能够继续研究早期生活压力的影响。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This project has three studies that utilize the cohorts of stressed and control nonhuman primates generated during the previous funding period of the Conte grant. Study 1 investigators examined the effects of early stress on subsequent cognitive abilities, with an emphasis on declarative and non-declarative memory functions. Study 2 investigators looked at the effects of early stress on the development of emotional behavior, with an emphasis on fear and anxiety, and changes in cerebral glucose metabolism. Study 3 investigator asked whether early stress results in acquiring cocaine self-administration more rapidly than control monkeys, and whether there is more resistance to extinction compared to control monkeys. The studies used structural and/or functional brain imaging to clarify the relationship between behavioral changes and changes in brain, and will look at neurochemical assessments to clarify the relation between behavioral changes and brain chemistry due to early life stress. Study 1 and Study 2 use the same groups of monkeys. This is both an efficient use of a very valuable resource that allows us to compare findings in two different domains of behavior, i.e., memory and emotion, in the same animals. By necessity, an entirely separate group of monkeys is being used for Study 3. Monkeys continued to be tested. Several have been fitted with telemetry implants and undergone PET studies. Study 3 monkeys are nearing completion of training. This was the final year of funding under the Conte Center grant. The animals are being reassigned to projects that will allow us to continue investigations into the effects of early life stress.