INTRATHECAL HUMORAL RESPONSES AND DEVELOPMENT OF SIV M-TROPIC VARIANTS IN CNS

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 中枢神经系统持续的SIV感染依赖于巨噬细胞嗜性(M嗜性)菌株，这些菌株通常很容易中和。因此，中枢神经系统通常被认为是促进M嗜性准种复制的免疫特权部位。然而，有关鞘内抗体反应或体液反应在控制M嗜性菌株方面的作用的数据有限。我们研究了鞘内中和活动的时间进程，发现中和的程度与M-嗜性种群的流行呈负相关。这些研究表明，在实验性SIV感染中，体液反应在抑制中枢神经系统中的M嗜性病毒种类中发挥了作用。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Sustained SIV infection of the CNS depends on macrophage-tropic (M-tropic) strains that are often easily neutralizable. Concomitantly, the CNS is often thought of as an immunologically privileged site that fosters replication of M-tropic quasispecies. Yet, there are limited data addressing the intrathecal antibody response or the role of the humoral response in general to control M-tropic strains. We investigated the temporal course of the intrathecal neutralizing activity and found an inverse relationship between the magnitude of neutralization and the prevalence of M-tropic populations. These studies suggest a role for the humoral response in the suppression of M-tropic viral species in the CNS in experimental SIV infection.