Core - Engineering Core

我们对记忆的神经机制的理解是通过对记忆的表征来推进的 行为动物的神经活动。项目2-3中描述的研究主要依赖于 用于同时记录多个神经元的活动和场电位的复杂设备 多个站点。出于某些目的，我们要求这些设备能够让我们灵活地对海马体进行采样 沿隔-颞轴有规则间距的神经元。对于项目3的最后目标，我们需要 能够在灵活选择的位置向神经元提供图案化的电刺激。发展和 这些装置的制造将通过建立专门的设施和工作人员来完成 将设计和建造多通道电极阵列，以及初步放大的前台 以及刺激多个部位的神经活动。工程核心还将作为一名将军 电子和机械商店为中心工作人员和学生服务。将培养工程核心人才 中心成员安全使用核心设备，并作为技术咨询来源。

Our understanding of the neural mechanisms of memory has been advanced by the characterization of neural activity in behaving animals. The research described in the Projects 2-3 depends crucially on sophisticated devices for simultaneous recording of the activity of multiple neurons and field potentials at multiple sites. For some aims, we require that these devices give us the flexibility to sample hippocampal neurons with regular spacing along the septotemporal axis. For the last aim of Project 3, we require the ability to deliver patterned electrical stimulation to neurons at flexibly chosen sites. Development and fabrication of these devices will be accomplished by establishment of a dedicated facility and personnel who will design and construct multichannel electrode arrays, as well as headstages for preliminary amplification and stimulation of neural activity at multiple sites. The Engineering Core will also serve as a general electronics and mechanics shop for Center personnel and students. Engineering Core personnel will train Center members in safe use of Core equipment and serve as a source of technical advice.