Chemistry Biology Interface Predoctoral Training Grant

描述（由申请人提供）：本申请申请第三次续期化学-生物界面（CBI）培训补助金。1995年，我们在马萨诸塞大学启动了一个新的跨学科培训项目，该项目建立在现有优势的基础上，并利用我们教师对物理科学和生命科学之间合作的承诺。我们成功地实施了一套课程，补充了参与研究生课程的要求，增加了足够的训练元素，以有效地培养具有互补学科化学或生物背景的学生。随后的一段时间（2000-2005年）是该计划的一个巨大增长时期：附属学生的数量从14人增加到60多人，因为远不止那些获得CBI资助的学生认识到CBI培训和社区的价值。在目前的资助期内，我们的CBI培训计划已成为校园的主要力量，影响着教师招聘和新建筑的建设和翻新。CBI培训学院已从19个发展到27个，并继续为化学、分子与细胞生物学、化学工程和高分子科学与工程四个研究生专业的60多名学生提供交叉培训。我们预计，随着更多的部门（特别是物理和计算机科学）进入CBI相关领域，我们的CBI计划将继续增长。CBI计划目前为6名博士预科生提供NIH支持，并为2名额外的培训生提供大学匹配支持。随着CBI项目扩展到新的学科和培养越来越多的学生，为了继续促进CBI项目不断增长的实力，我们要求将美国国立卫生研究院资助的培训生名额增加到8个。我们的CBI项目的显著特点包括化学工程系和高分子科学与工程系的参与，这丰富了CBI培训与定量，生物材料和生物工程的观点和项目。我们广受欢迎的“药物设计”课程是CBI课程的一个组成部分，每周都有来自制药行业的演讲者参加研讨会，并有实地考察公司的机会。我们的CBI静修已经发展成为一个充满活力的年度活动，与麻省大学医学院的研究人员建立联系。最后，CBI学生与新成立的麻省理工大学蜂窝工程学院的学生合作，正在组织新的年度职业日，以进一步加强他们的CBI培训。因此，CBI课程和社区为化学和生物学的方法和知识框架提供了丰富的培训机会，这为我们的CBI毕业生在未来的工作中提出和解决重要的生物医学问题做好了准备。

DESCRIPTION (provided by applicant): This application requests the third renewal of our Chemistry-Biology Interface (CBI) Training Grant. In 1995 we launched a new interdisciplinary training program at the University of Massachusetts that built on existing strengths and harnessed our faculty commitment to collaboration between the physical and life sciences. We successfully implemented a curriculum that complemented the requirements of the participating graduate programs, adding enough training elements to efficiently train students with either chemical or biological backgrounds in the complementary discipline. The subsequent period (2000-2005) was one of tremendous growth of the program: the number of affiliated students grew from 14 to over 60, as students well beyond those with CBI funding recognized the value of the CBI training and community. During the current funding period our CBI Training Program has become a major force on campus, influencing faculty hiring and construction of new buildings and renovations. The CBI Training Faculty has grown from 19 to 27, and continues to provide cross-training to over 60 students from the four participating graduate programs of Chemistry, Molecular & Cellular Biology, Chemical Engineering, and Polymer Science & Engineering. We anticipate continued growth of our CBI Program as additional departments (notably Physics and Computer Science) move into CBI- related areas. The CBI Program currently provides NIH support for 6 pre-doctoral students, and a University match supports 2 additional Traineeships. To continue to foster the growing strength of the CBI program as it expands into new disciplines and trains increasing numbers of students, we request an increase to 8 NIH-funded Traineeships. Notable features of our CBI Program include the participation of the Departments of Chemical Engineering and Polymer Science & Engineering, which enriches CBI training with quantitative, biomaterials, and bioengineering perspectives and projects. Our popular "Drug Design" course, developed as an integral part of the CBI curriculum, features weekly seminars by speakers from the pharmaceutical industry and a field trip to tour a company. Our CBI retreat has grown into a vibrant annual event that forges connections with researchers at UMass Medical School. Finally, CBI students, in partnership with students of the new UMass Institute for Cellular Engineering, are organizing a new annual Career Day to further enhance their CBI training. Thus the CBI curriculum and community are rich in opportunities for training in the methods and intellectual framework of both chemistry and biology, which prepares our CBI graduates to pose and solve significant biomedical questions in their future work. PUBLIC HEALTH RELEVANCE: Understanding the causes of a disease and developing new treatments requires scientists to apply the concepts and methods of both chemistry and biology. Graduate students pursuing the Ph.D. in either chemical or biological sciences at UMass have the opportunity to be trained in the complementary discipline through the curriculum and interactions of the Chemistry-Biology Interface (CBI) Training Program. This training prepares them for productive careers in the biomedical sciences in industrial, academic, or governmental laboratories.