Training in Developmental Cardiovascular Biology

描述（由申请人提供）：此更新提案寻求延续26年前启动的发育心血管生物学计划的培训。在过去10年中，该计划资助的14名完成培训的研究员中，有8名在优秀机构获得学术任命，所有14名研究员都积极参与联邦或私人资助的研究项目。该项目将继续利用心血管研究所优秀的生理学、分子和细胞生物学实验室以及加州大学旧金山分校的几个部门来培养未来几十年将站在心血管研究发展前沿的基础科学家。现代生理学和分子生物学方法在我们的心血管生物学和疾病知识方面取得了显著进展，人类遗传学和干细胞生物学领域提供了更多的机会。这些发展预示着快速的科学进步，并强调需要训练有素的研究人员继续这项工作，并在基本发现和人类健康的进步之间建立桥梁。为此，我们将：1)利用CVRI、儿科和加州大学旧金山分校在基础生物学领域的独特培训机会；2)招收优秀博士和医学博士毕业生。心血管研究的职业规划；3)将临床儿科心脏病学培训与严格的基础研究结合起来，以促进医师-科学家的培训。该基金将资助4名博士后，每名2年，并设有两个研究方向。轨道一，新命名的医师-研究者途径，将支持医学博士学员寻求临床儿科心脏病学和基础科学研究培训。本专业的学员只会在其培训的研究部分获得培训补助金。轨道二将支持博士或医学博士。将公开竞争基础心血管生物学博士后职位的学员。一个强大的教学课程将提供在一个丰富的科学环境，严谨的研究生课程，定期见习会议，细心的指导。每位学员将与22名优秀的项目教师导师之一一起执行一个研究项目。

DESCRIPTION (provided by applicant): This renewal proposal seeks continuation of the Training in Developmental Cardiovascular Biology program, initiated 26 years ago. Of the 14 fellows supported by this program during the preceding 10 years who have completed training, 8 have academic appointments at outstanding institutions and all 14 are actively engaged in federally- or privately-funded research programs. This program will continue to utilize the outstanding physiology and molecular and cellular biology laboratories at the Cardiovascular Research Institute and several UCSF departments to train basic scientists who will be at the forefront of developmental cardiovascular research in the coming decades. Modern physiologic and molecular approaches have produced remarkable advances in our knowledge of cardiovascular biology and disease, and the fields of human genetics and stem cell biology are providing still more opportunities. These developments promise rapid scientific progress and underscore the ongoing need for well-trained investigators to both continue this work and build bridges between basic discovery and the advancement of human health. To this end we will: 1) exploit the unique training opportunities in the CVRI, the Department of Pediatrics, and UCSF in general in areas of basic biology; 2) recruit graduates of top Ph.D. and M.D.-Ph.D. programs to careers in cardiovascular research; and 3) combine clinical pediatric cardiology training with a rigorous grounding in basic research to facilitate the training of physician-scientists. This grant will support 4 postdoctoral fellows, each for 2 years, and features two tracks. Track I, the newly named Physician-Investigator Pathway, will support M.D. trainees seeking both clinical pediatric cardiology and basic science research training. Trainees in this Track will receive support from this training grant only for the research component of their training. Track II will support Ph.D. or M.D.-Ph.D. trainees who will compete openly for postdoctoral positions in basic cardiovascular biology. A strong didactic curriculum will be provided in a rich scientific environment with rigorous graduate courses, regular trainee meetings, and attentive mentorship. Each trainee will execute a research project with one of the 22 outstanding program faculty preceptors.