Research Training in Pediatric Cardiology

描述(由申请人提供)：本申请请求继续资助T32 HL 007710，目的是提高专注于儿科心血管疾病的成功临床和翻译研究人员的数量和质量。在这笔赠款的头14年里，资助的35名受训人员的研究效率和学术生涯进步都是巨大的。在这个竞争性的更新申请中，我们描述了在以患者为中心和转化性研究中培训和指导儿科心脏病学研究员的计划，这些研究侧重于儿科心脏病学中的重大挑战。该计划为儿科心脏病学(MD)研究员提供了两条模范研究培训途径：临床研究人员和转化型临床医生科学家途径。每个学员都将有一个由临床和基础科学导师组成的L初级导师和指导团队，从而增加了可用于促进职业发展的想法和经验的广度。该计划为每个受训者确定和促进理想的个性化培训目标，以最大限度地增加他或她成为具有可持续竞争力的多产学术研究人员的机会，以支持校外研究。MUSC的科学和计划资源被整合到这一研究培训计划中，包括作为NHLBI儿科心脏网络的主要临床中心参与；蓬勃发展的儿科心脏病学临床研究员培训计划；儿科心脏病学和儿科心脏外科的协作临床教员，拥有广泛的出版物、研究资金和参与多机构研究的记录；在心血管发育生物学、心脏形态发生、细胞外基质生物学、心肌肥大、重塑、伤口愈合、细胞修复、干细胞生物学、组织工程、生物工程和假体设备开发方面的杰出教员力量；通过NIH资助的CTSA计划，在临床研究方法学方面提供广泛的教学培训机会；成熟、成功的临床研究理学硕士学位课程；临床和基础科学研究环境，已被证明成功招募少数族裔；坚定的机构承诺；达比儿童研究所；以及NIH/NCRR心血管发育生物学卓越生物医学研究中心(COBRE)。一份综合的多年评估计划将记录和评估达到计划目标和目的的程度，并为持续改进和加强提供关键信息。

DESCRIPTION (provided by applicant): This application requests continued support of grant T32 HL 007710 with the goal of increasing the number and quality of successful clinical and translational investigators focused on pediatric cardiovascular disease. The research productivity and academic career advancement of the 35 trainees supported during the first 14 years of this grant are substantial. In this competing renewal application, we describe plans for training and mentoring pediatric cardiology research fellows in patient-oriented and translational research focused on significant challenges in pediatric cardiology. The program has two model research training pathways for pediatric cardiology (MD) fellows: the Clinical Investigator and Translational Clinician Scientist Pathways. Each trainee will have a Primary l\/ lentor and Mentoring Team composed of both clinical and basic science mentors, thereby increasing the breadth of ideas and experience available to enhance career development. The program identifies and promotes desirable individualized training goals for each trainee in order to maximize his or her opportunity to become a productive academic investigator with sustainable competitiveness for extramural research support. Scientific and programmatic resources at MUSC that are integrated into this research training program include participation as a primary Clinical Center in the NHLBI Pediatric Heart Network; a thriving clinical pediatric cardiology fellowship training program; a collaborative clinical faculty in pediatric cardiology and pediatric cardiac surgery with an extensive track record of publications, research funding and participation in multi-institutional studies; exceptional faculty strengths in cardiovascular developmental biology, cardiac morphogenesis, extracellular matrix biology, cardiac hypertrophy, remodeling, wound healing, cellular repair, stem cell biology, tissue engineering, bioengineering and prosthetic device development; a wide array of didactic training opportunities in clinical research methodology through the NIH-funded CTSA program; a well-developed, successful Master of Science in Clinical Research degree program; clinical and basic science research environments with proven minority recruitment success; substantial institutional commitment; the Darby Children's Research Institute; and an NIH/NCRR Center of Biomedical Research Excellence (COBRE) in cardiovascular developmental biology. An integrated multi-year evaluation plan will document and assess the extent to which program goals and objectives are met and provide critical information for ongoing improvement and enhancement.