UNMC Eppley Cancer Center Support Grant

描述(由申请人提供)：UNMC Eppley癌症中心是内布拉斯加州大学医学中心(UNMC)指定的NCI指定的矩阵临床癌症中心，开展广泛的基础、临床、转化和人口科学癌症研究。癌症中心主任直接向UNMC校长报告，也是Eppley癌症研究所的主任，这是一个拥有30名教员的多学科基础癌症研究机构。NCI为癌症中心定义的同行评审资金目前为2393万美元(年度直接成本)，自1999年以来增长了2.2倍，其中来自NIH的1850万美元(自1999年以来增长了2.4倍)和NCI的599万美元(增长了25%)。自上次审查以来，癌症中心一直在进行积极而战略性的招聘，结果新增了35名癌症研究人员(22名基础科学研究人员和13名临床/翻译研究人员)，在癌症遗传学、动物模型、DNA修复、细胞信号和结构生物学等几个关键研究领域增加了显著实力。癌症中心继续得到内布拉斯加州和UNMC的大力支持。2003年，国家和机构对癌症中心的支持为1395万美元。国家支持为教师招聘和共享资源增强提供了资源，包括新的600 MHz核磁共振、基因阵列设施、X射线结晶学设施，以及对动物设施的升级。一座新的UNMC 286,000平方英尺的研究大楼(将于2/04开放)将允许巩固前列腺癌、癌症遗传学和药物输送研究项目。2003年，癌症中心还被分配了额外的43,000平方英尺的研究空间，以便继续增长，使主任授权的总空间达到200,000平方英尺。癌症中心有三个动态研究项目：1)癌症基因和分子调控；2)癌症分子和生化病因学；3)实验治疗学。通过几个面向疾病的多学科工作组，包括乳腺癌、前列腺癌、胰腺癌和血液系统恶性肿瘤，促进了翻译研究。癌症中心还支持14个共享资源：动物护理、生物信息学、生物统计学、细胞分析、临床试验办公室、共焦显微镜、组织学、实验室支持、质谱学、分子生物学、单抗、核磁共振、安全和组织采购。

DESCRIPTION (provided by applicant): The UNMC Eppley Cancer Center is an NCI-designated matrix Clinical Cancer Center at the University of Nebraska Medical Center (UNMC) conducting a wide range of basic, clinical, translational and population science cancer research. The Cancer Center Director reports directly to the Chancellor of UNMC, and also serves as Director of the Eppley Institute for Cancer Research, a multidisciplinary basic cancer research institute with 30 faculty. NCI-defined peer-reviewed funding for the Cancer Center is currently $23.93 million (annual direct costs), a 2.2 fold increase since 1999, with $18.5 million from NIH (2.4 fold increase since 1999) and $5.99 million from NCI (25% increase). Since the last review, the Cancer Center has pursued vigorous, but strategic, recruitment resulting in 35 new cancer research faculty (22 basic science and 13 clinical/translational researchers) adding significant strength in several key research areas including cancer genetics, animal models, DNA repair, cell signaling, and structural biology. The Cancer Center continues to enjoy outstanding support from the state of Nebraska and UNMC. In 2003, state and institutional support to the Cancer Center was $13.95 million. State support provided resources for faculty recruitment and shared resource enhancements, including a new 600 MHz NMR, a gene array facility, an X-ray crystallography facility, and upgrades to the animal facility. A new UNMC 286,000 sq ft research building (to open 2/04) will allow consolidation of prostate cancer, cancer genetics and drug delivery research programs. In 2003, the Cancer Center was also assigned an additional 43,000 sq ft of research space to allow continued growth, bringing the total amount of space under the authority of the Director to 200,000 sq ft. The Cancer Center has three dynamic research programs: 1) Cancer Genes and Molecular Regulation; 2) Molecular and Biochemical Etiology of Cancer; and 3) Experimental Therapeutics. Translational research is facilitated through several multidisciplinary disease-oriented working groups including breast cancer, prostate cancer, pancreatic cancer, and hematological malignancies. The Cancer Center also supports fourteen shared resources: Animal Care, Bioinformatics, Biostatistics, Cell Analysis, Clinical Trials Office, Confocal Microscopy, Histology, Laboratory Support, Mass Spectrometry, Molecular Biology, Monoclonal Antibody, Nuclear Magnetic Resonance, Safety, and Tissue Procurement.