COMMUNITY BASED RESEARCH AND EDUCATION (COBRE) CORE FACILITY

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 CTN将在转化神经科学领域建立一个新的核心设施。 转化研究的一个定义是将基础科学发现应用于临床。 然而，在这种情况下，我们将转化神经科学定义为利用生物医学知识和研究来解决社区中的真实的问题。 在本测试案例中，我们将解决儿童的健康问题，因此核心设施将设在阿肯色州儿童医院（ACH）。 低出生体重（LBW）出生是婴儿死亡和残疾的主要原因，是父母压力的主要来源，也是私人和公共健康保险计划的经济负担。 在提供专业产前和围产期护理的医院分娩被认为能有效改善分娩结果，并可能降低医疗费用。 然而，居住在农村和服务不足地区的妇女通常无法进入这些中心，也无法获得孕产妇和胎儿医学专科医生的帮助，这些专科医生可以帮助社区医生诊断和管理高危疾病。 CTN将开始一项为期一年的核心设施支持试验，该核心设施将采用一个由15个交互式压缩视频网站组成的全州网络，一个集中的24小时呼叫中心，以及一个全州医生教育和指南制定计划，使妇女及其社区医生能够咨询学术专家，并促进基于证据的高危妇女转诊到区域围产期中心分娩。 除了这些教育活动外，COBRE核心设施将开始收集关于生育结果的研究数据。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The CTN will implement a new Core Facility in translational neuroscience. One definition of translational research is the application of basic science findings to the bedside. However, in this context, we define translational neuroscience as using biomedical knowledge and research to solve real problems in the community. In this test case, we will address children's health issues so that the Core Facility will be based at Arkansas Children's Hospital (ACH). Low birth weight (LBW) births are a leading cause of death and disability in infants, major sources of stress for parents, and an economic burden for private and public health insurance programs. Delivery at hospitals offering specialized pre- and perinatal care is thought to be effective in improving birth outcomes and perhaps reducing medical costs. However, women residing in rural and underserved areas typically lack access to these centers and to maternal and fetal medicine subspecialists who can assist community physicians with diagnosis and management of high-risk conditions. The CTN will begin a one-year trial of support for a Core Facility that will employ a statewide network of 15 interactive compressed video sites, a centralized 24-hour call center, and a statewide physician education and guideline development initiative to enable women and their community physicians to consult with academic subspecialists and facilitate the evidence-based referral of high-risk women to regional perinatal centers for delivery. In addition to these educational activities, the COBRE Core Facility will begin to gather research data on birth outcomes.