CORE A: ADMINISTRATIVE CORE

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 管理核心是COBRE的“中枢神经系统”，作为COBRE的管理中心和检查点，指导初级研究者的有效发展。行政核心还将帮助初级研究者减轻与研究项目相关的行政职责（即，赠款管理、人类受试者培训、IRB申请和合规性、IACUC申请和合规性、旅行安排、预算管理、人类受试者登记以及人员招募和保留）。行政核心将为演讲准备、会议、研讨会、重要的科学访问者和手稿准备提供便利。内部（IAC）和外部（EAC）咨询委员会会议将在行政核心的主持下举行。他们的决定将由行政核心执行。行政核心将向内部和外部咨询委员会提交进度报告。行政核心将包括主要和共同主要调查员、导师和助理导师、内部和外部咨询委员会以及COBRE管理员。初级研究者的R 01提案将由行政核心推动和批评，并安排内部和外部审查员。行政核心将处理和评估由招聘核心确定的合格的潜在初级研究者的提案。预计新的初级研究者将对自身免疫性有职业兴趣，可能在俄克拉荷马州，但在招聘时更有可能在其他地方工作。新的COBRE初级研究者的机会将发生在当前的初级研究者获得R 01 NIH资助并从COBRE支持中“毕业”或以其他方式与COBRE支持分离时。 所有四个行政核心组成部分（外部咨询委员会，内部咨询委员会，导师和COBRE管理）将努力实现COBRE在俄克拉荷马州建立研究基础设施和培养独立调查员的目的。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. The Administrative Core is the "central nervous system" of this COBRE functioning as governing center and the checkpoint of the COBRE, mentoring effectiveness Junior Investigator development. The Administrative Core will also help unburden the Junior Investigators with the administrative duties associated with research projects (i.e., grants management, human subject training, IRB application and compliance, IACUC application and compliance, travel arrangements, budget management, human subject enrollment, and personnel recruitment and retention). The Administrative Core will facilitate presentation preparations, meetings, seminars, important scientific visitors, and manuscript preparation. The Internal (IAC) and External (EAC) Advisory Committee meetings will be held under the auspices of the Administrative Core. Their decisions will be implemented by the Administrative Core. The Administrative Core will make progress reports to the Internal and External Advisory Committees. The Administrative Core will consist of the Principal and Co-Principal Investigators, the Mentors and Assistant Mentors, the Internal and External Advisory Committees and the COBRE Administrator. The R01 proposals by Junior Investigators will be facilitated and criticized by the Administrative Core, where internal and external reviewers will be arranged. The Administrative Core will process and evaluate proposals from qualified prospective Junior Investigators ascertained by the Recruiting Core. New Junior Investigators are expected to have a career interest in autoimmunity, and may be in Oklahoma and but are more likely to be working elsewhere at the time of recruitment. Opportunity for new COBRE Junior Investigators will occur as the current Junior Investigators obtain R01 NIH funding and "graduate" from COBRE support or otherwise separate from COBRE support. All four Administrative Core components (the External Advisory Committee, the Internal Advisory Committee, Mentors, and COBRE Administration) will work toward realizing the COBRE purposes of building research infrastructure in Oklahoma and of developing independent investigators.