Mouse/Human Chimera Core

体内模型对于理解病毒性疾病至关重要。缺乏动物模型， 人类免疫缺陷病毒1型（HIV-1）感染后的病理学阻碍了我们对 与发病机制相关的病毒机制。人/免疫缺陷小鼠的发展 嵌合体提供了新的模型系统，用于研究人类免疫系统和嵌合体的作用。 艾滋病毒感染人体细胞和组织。这些模型涉及各种类型的人的移植。 组织移植到具有几种免疫缺陷的小鼠体内。这些缺陷阻止了拒绝 通过宿主的移植组织，从而提供用于培养人体组织的体内环境。 CFAR支持的小鼠/人类嵌合体核心旨在协助UCLA的艾滋病研究人员， 通过提供最先进的人类/小鼠嵌合体技术和适当的动物 住房设施。该设施将提供和住房的几种类型的免疫缺陷小鼠艾滋病相关的 在生物安全2级和生物安全2+级条件下进行研究。该设施还将提供 就嵌合模型的使用进行咨询，以及构建各种小鼠/人嵌合动物， 分发给核心用户。

In vivo models are critical to the understanding of viral diseases. The lack of animal models that display pathology following infection with human immunodeficiency virus type 1 (HIV-1) has hindered our knowledge of the viral mechanisms associated with pathogenesis. The development of human/immunodeficient mouse chimeras has provided novel model systems with which to study the human immune system and the effect of HIV infection on human cells and tissues. These models involve transplantation of various types of human tissues into mice who possess one of several types of immune defects. These defects prevent the rejection of the transplanted tissue by the host, thereby providing an in vivo environment for culturing human tissue. The CFAR-supported Mouse/Human Chimera Core is designed to assist AIDS investigators at UCLA with their research by providing state-of-the-art human/mouse chimera technologies and appropriate animal housing facilities. This facility will supply and house several types of immunodeficient mice for AIDS-related research under both Biosafety Level 2 and Biosafety Level 2+ conditions. This facility will also provide consultation on the use of chimeric models, as well as construct various mouse/human chimeric animals for distribution to Core users.