DTS Imaging with a Digitally Addressable X-Ray Source (DAXS)

描述(申请人提供)：使用数字可寻址X射线源(DAXS)的DTS成像摘要4-D X射线成像将为涉及对比剂注射或解剖运动的成像过程提供强大的工具。在这项研究中，我们计划开发和研究一种基于数字断层合成(DTS)和数字可寻址X射线源(DAXS)的四维X射线成像系统。DAXS允许在平板X射线面板上的任何数字选择位置产生X射线。这将使我们能够设计和构建一个不包含任何移动部件的静止DTS系统。由于消除了物理移动部分，扫描速度可以大大提高，从而允许进行4-D成像，利用该成像可以对运动解剖或注射的造影剂的3-D图像进行成像和监视。DAXS的使用还允许X射线源以2-D模式进行数字移位，导致更有效地模糊焦平面外的对象和更好的面内对象的对比度。这项拟议的研究包括在两个不同的地点进行的两个主要部分：位于德克萨斯州奥斯汀的STELLAR微设备公司(SMD)的子公司STELLARY Inc.和位于德克萨斯州休斯顿的德克萨斯大学安德森癌症中心(MDACC)的数字成像研究实验室(DIRL)。这两个网站的接近鼓励了积极的合作和互动。在这次学术-产业合作中，DAXS技术将在SMD开发，并提供给MDACC-DIRL，以实施和研究用于4-D成像的DTS技术。将对操作参数和图像质量指标进行调查和优化。将进行人体模型实验来演示和验证所提出的4-D X射线成像技术。在这项合作中，每个地点将有一名独立的首席调查员(PI)。MDACC PI还将作为联系和协调PI。

DESCRIPTION (provided by applicant): DTS imaging with a Digitally Addressable X-ray Source (DAXS) Abstract 4-D x-ray imaging would provide a powerful tool for imaging procedures involving contrast injection or anatomical motions. In this research, we propose to develop and investigate a 4-D x-ray imaging system based on digital tomosynthesis (DTS) and a digitally addressable x-ray source (DAXS). The DAXS allows x-rays to be generated at any digitally selected location on a flat x-ray panel. This would enable us to design and construct a stationary DTS system that contains no moving parts. Due to the elimination of physically moving parts, the scan speed can be substantially increased, thus allowing for 4-D imaging, with which 3-D images of moving anatomy or injected contrast materials can be imaged and monitored. The use of a DAXS also allows the x-ray source to be digitally shifted with a 2-D pattern, leading to more effective blurring of the out of focal plane objects and better contrast of the in plane objects. The proposed research consists of two major parts carried out at two different sites: Stellarray Inc., a subsidiary of Stellar Micro Devices, Inc. (SMD) at Austin, TX and the Digital Imaging Research Laboratory (DIRL) at the U. of Texas M. D. Anderson Cancer Center (MDACC) at Houston, TX. The closeness of the two sites encourages active collaboration and interaction. In this Academic-Industry collaboration, the DAXS technology will be developed at SMD and provided to MDACC-DIRL to implement and investigate the DTS techniques for 4-D imaging. Operation parameters and image quality metrics will be investigated and optimized. Phantom experiments will be performed to demonstrate and validate the proposed 4-D x-ray imaging techniques. In this collaboration, there will be a separate Principal Investigator (PI) at each site. The MDACC PI will also serve as the contact and coordinating PI.