TRANSGENIC AND TARGETING

凯斯转基因和靶向核心设施是产生转基因小鼠用于 Case综合癌症中心(Case CCC)和克利夫兰生物医学社区。该设施 制造转基因和基因靶向的小鼠，除了进行再衍生，体外受精， 冷冻保存等服务。该设施有四名员工和一名董事。该服务有一个 实验室套房面积约1700平方英尺，毗邻最先进的动物设施，并配备 四个显微注射站，两个组织培养罩和三个手术罩。该设施运行在一个 按服务收费，并为所有服务提供咨询。该设施支持这一案件 全面的癌症中心使命通过生成癌症的小鼠模型，以及工具和 基础科学问题调查材料。该设施尚未得到该案的支持 之前的CCC。2004年和2005年，CASE CCC成员占该设施使用量的42%。 Case CCC的支持将用于额外雇用一名工作人员，以确保服务 不会发生积压。此外，Case CCC成员将受益于服务的折扣费用， 低于学术平均水平。

The Case Transgenic & Targeting Core Facility is the sole service generating genetically modified mice for the Case Comprehensive Cancer Center (Case CCC) and the Cleveland Biomedical community. The facility makes transgenic and gene-targeted mice, in addition to performing rederivations, in vitro fertilization, cryopreservation, and other services. The facility has a staff of four and a director. The service has a laboratory suite of about 1700 square feet adjacent to a state-of-the-art animal facility, and is equipped with four microinjection stations, two tissue culture hoods, and three surgery hoods. The facility operates on a fee-for-service basis, and provides consultation with all services. The facility supports the Case Comprehensive Cancer Center mission through the generation of mouse models of cancer, and tools and materials for investigation of basic science questions. The facility has not received support from the Case CCC previously. Case CCC members accounted for 42% of the use of the facility in 2004 and 2005. Support from the Case CCC would be used to hire an additional staff member to ensure that service backlogs do not occur. In addition, Case CCC members would benefit from discounted fees for services, at less than the academic average.