Console upgrade for microimaging and solid state NMR spectroscopy at 600 MHz

描述（由申请人提供）：申请资金用于更换佛罗里达大学高级磁共振成像和光谱设施中的600 MHz核磁共振光谱仪的11年旧核磁共振控制台。目前的布鲁克DRX控制台主要用于高分辨率显微成像和固态NMR实验，相对于下一代控制台而言在技术上受到限制，并且开始频繁出现故障，供应商不再支持几个组件。请求提供资金，以Bruker Avance III控制台替换这台老化的控制台。除了提高核磁共振设备的可靠性外，新的控制台和集成软件预计将具有增强的技术能力和相对于我们现有控制台的改进性能。AMRIS设施支持广泛的NIH资助的研究项目，拥有四名专门的技术人员，他们在显微成像，NMR光谱学和动物MRI方面具有专业知识，并在生物MR研究方面拥有60多年的工作经验。新的控制台对NIH资助的八个主要用户（S。Blackband，G. Fanucci，J. Long，T. Mareci，M. Sarntinoranont，N.辛普森，B。Vemuri和G.沃尔特），他们都是显微成像和/或生物分子核磁共振的专家，和小用户（包括M。Raizada，E. Scott和D. Steindler）。这些用户组进行的研究是非常苛刻的成像和光谱学的角度来看，包括测量组织结构和扩散在细胞分辨率和测量生物分子结构和动态通过固态NMR光谱。一些项目与人类疾病的诊断和治疗直接相关。 公共卫生相关性：磁共振成像和波谱学是一种强大的连续技术，用于研究生物系统中的三维结构、扩散、分子结构和动力学。佛罗里达大学的一些NIH支持的研究人员利用磁共振技术研究与人类健康和疾病相关的生物组织和生物分子。要求提供资金，用最先进的设备更换过时的MRI/S设备，以确保与该应用相关的研究人员的生物和生物医学研究计划以及在研究中也依赖MR的更多用户的更大社区继续取得进展。

DESCRIPTION (provided by applicant): Funds are requested for the replacement of an 11 year old NMR console for a 600 MHz NMR spectrometer located in the Advanced Magnetic Resonance Imaging and Spectroscopy Facility at the University of Florida. The current Bruker DRX console, primarily utilized for high resolution microimaging and solid state NMR experiments, is technically limited relative to next generation consoles and is beginning to break down on a frequent basis, with several components no longer supported by the vendor. Funds are requested to replace this aging console with a Bruker Avance III console. In addition to enhancing the reliability of the NMR equipment, the new console and integrated software are expected to have enhanced technical capabilities and improved performance relative to our current console. The AMRIS Facility supports a broad range of NIH-funded research projects with four dedicated technical staff having expertise in microimaging, NMR spectroscopy, and animal MRI and over 60 years of experience working in biological MR research. The new console is critical to the success of the NIH-funded research of both a group of eight major users (S. Blackband, G. Fanucci, J. Long, T. Mareci, M. Sarntinoranont, N. Simpson, B. Vemuri, and G. Walter), all of whom are experts in microimaging and/or biomolecular NMR, and of minor users (including M. Raizada, E. Scott, and D. Steindler). These user groups undertake studies that are extremely demanding from an imaging and spectroscopy standpoint, including measurements of tissue structure and diffusion at cellular resolution and measurements of biomolecular structure and dynamics via solid state NMR spectroscopy. A number of the projects are of direct relevance to the diagnosis and treatment of human disease. PUBLIC HEALTH RELEVANCE: Magnetic resonance imaging and spectroscopy is a powerful continuum of techniques used to study the three-dimensional structures, diffusion, and molecular structure and dynamics in biological systems. A number of NIH-supported investigators at the University of Florida utilize magnetic resonance techniques to study biological tissues and biomolecules of relevance to human health and disease. Funds are requested to replace out-of-date MRI/S equipment with state-of-the-art equipment to ensure continued progress of the biological and biomedical research programs of the investigators associated with this application and a larger community of additional users who also rely on MR in their investigations.