PROGRAM ADMINISTRATION AND PROJECT COORDINATION

行政核心单位的目标是协调和提供科学的领导， 该计划项目，以鼓励有效地结合工作人员的科学利益， 确保研究各阶段的质量控制，监督项目数据库的维护 这将作为一个数据库，允许事后数据挖掘，以确保遵守 NIH的要求，从而指导整个计划圆满结束。PI有一个 继续致力于促进和支持调查人员之间的有效工作关系 具有互补的科学兴趣，理论观点和方法。本 在这种情况下，核心将通过以下方式推进这一议程：（1）为例行合议庭创造机会！ 讨论与计划项目有关的共同利益;（2）定期征求以下方面的意见： 具有广泛科学兴趣的外部评审员;以及（3）鼓励联合传播 通过科学会议，学术出版物和互联网的研究成果。 核心有两个次要目标。首先，核心将使研究更有效率， 通过集中研究支持的某些方面来提高成本效益。第二，也许更多 重要的是，该核心将促进与NICHD支持的P30的适当交互 MRDDRC基金（请参阅参考资料）将部分抵消研究计划的成本。 值得注意的是，拟议计划项目的PI也是P30赠款的PI，从而促进 两个供资来源之间的有效资源协调。 参与项目的人员，包括顾问/合作者。使用续页作为 需要以下列格式提供参与项目的所有个人的必要信息。 主要研究者：W. J. Mcllvane博士，主任，UMMS施赖弗中心主任，UMMS 智力迟钝发育障碍研究中心 第二百四十五页 精神发育迟滞的刺激控制研究 核心A：Mcllvane 1.目标 行政核心单位的目标是：（1）为 （2）有效整合员工的科学兴趣，（3）确保 在研究的所有阶段进行质量控制，（4）监督项目数据库的维护， 将作为一个存储库的数据，将允许事后数据挖掘，（5）确保程序 项目满足任何当前和未来的数据共享和安全监测需求， 引导整个项目取得圆满成功。PI持续承诺 促进和支持调查人员之间的有效工作关系， 科学兴趣、理论观点和方法。在目前的情况下，核心将 通过以下方式推进这一议程：（1）为例行合议庭创造机会！讨论共享 与计划项目相关的利益;（2）定期征求外部评审员的意见， 广泛的科学兴趣;（3）鼓励通过科学方法联合传播研究成果 会议、学术出版物和互联网。 核心有两个次要目标。首先，它将使研究更加有效和成本- 通过集中研究支持的某些方面有效。第二，也许更多 重要的是，该核心将促进与NICHD支持的P30的适当交互 MRDDRC赠款（见下文资源部分）将部分抵消 研究计划。值得注意的是，拟议计划项目的PI也是P30赠款的PI， 从而促进两个供资来源之间的有效资源协调。 2.人员配置 博士William J. Mcllvane（项目总监，P01赠款支持请求：12%努力） 担任项目经理10年以上。他将负责 计划的整体科学和行政指导和协调。他的主要职责 将确保研究计划及时实施，忠实于 它的具体目标，并保持最高标准的科学质量和完整性。他会帮助 设定中期研究目标，例如，监测实现这些目标的进展，并监督 为国家排雷中心编写进度报告。通过这些活动和其他形式的日常 联系，Mclvane博士将确保该计划项目的每一位高级研究人员都能收到 定期从同事和项目科学顾问那里得到工作反馈 以马克思 女士卡罗尔科廷（通讯主任，P01赠款支持要求：5%，在第一年， （如有需要）主要负责促进内部沟通， 在施莱佛中心外面在第一年，她将负责开发一个信息丰富的，用户- 友好的网站和由MRDDRC的临床和翻译编写的小册子的附录 研究中心协助招募适合其每个组成部分的研究参与者 项目 女士Cynthia Kinahan（部门管理员）和Donna Caira女士（行政 助理）将为项目提供一般行政支持。其职能将是 由施莱佛中心预算资助杰弗里·贝克先生是一位-

The objectives of the administrative core unit are to coordinate and provide scientific leadership for the program project, to encourage effective integration of the scientific interests of the staff, to ensure quality control in all phases of the research, to oversee maintenance of a project database that will serve as a repository of data to permit post-hoc data mining, to assure compliance with NIH requirements, and thus to guide the overall program to a successful conclusion. The PI has a continuing commitment to foster and support effective working relationships between investigators with complementary scientific interests, theoretical perspectives, and methods. In the present context, the core will advance this agenda by: (1) setting the occasion for routine collegia! discussions of shared interests relevant to the program project; (2) soliciting regular input from external reviewers with broad scientific interests; and (3) encouraging joint dissemination of research findings via scientific conferences, scholarly publications, and the Internet. The core has two secondary objectives. First, the core will make the research more efficient and cost-effective by centralizing certain aspects of research support. Second, and perhaps more importantly, the core will facilitate appropriate interactions with the NICHD-supported P30 MRDDRC grant (see Resources) that will partially offset the costs of the research program. Notably, the PI of the proposed program project is also the PI of the P30 grant, thus facilitating effective resource coordination between the two funding sources. PERSONNEL ENGAGED ON PROJECT, INCLUDING CONSULTANTS/COLLABORATORS. Use continuation pages as neededto provide the required information in the format shown below on all individuals participating in the project. Principal Investigator: W. J. Mcllvane, Ph.D., Director, UMMS Shriver Centers Director, UMMS Mental Retardation Developmental Disabilities Research Center Page 245 Studies of Stimulus Control in Mental Retardation William J. Mcllvane, Ph.D. Core A: Mcllvane 1. Objectives The objectives of the administrative core unit are to: (1) provide intellectual leadership for the program project, (2) encourageeffective integration of the scientific interests of the staff, (3) ensure quality control in all phases of the research, (4) oversee maintenance of a project database that will serve as a repository of data that will permit post-hoc data mining, (5) assure that the program project meets any current and future needs for data sharing and safety monitoring, and thus to guide the overall program to a successful conclusion. The PI has a continuing commitment to foster and support effective working relationships among investigators with complementary scientific interests, theoretical perspectives, and methods. In the present context, the core will advance this agenda by: (1) setting the occasion for routine collegia! discussions of shared interests relevant to the program project; (2) soliciting regular input from external reviewers with broad scientific interests; and (3) encouraging joint dissemination of research findings via scientific conferences, scholarly publications, and the Internet. The core has two secondary objectives. First, it will make the research more efficient and cost- effective by centralizing certain aspects of research support. Second, and perhaps more importantly, the core will facilitate appropriate interactions with the NICHD-supported P30 MRDDRC grant (see Resources section and below) that will partially offset the costs of the research program. Notably, the PI of the proposed program project is also the PI of the P30 grant, thus facilitating effective resource coordination between the two funding sources. 2. Staffing Dr. William J. Mcllvane (Program Director, P01 grant support requested: 12%effort) has been the program project director for more than 10 years. He will have responsibility for the program's overall scientific and administrative direction and coordination. His main responsibility will be to ensure that the research program is implemented in a timely fashion, remains faithful to its specific aims, and maintains the highest standards of scientific quality and integrity. He will help to set interim research goals, for example, to monitor progress in achieving them, and to supervise preparation of progress reports for NICHD. Through these activities and other forms of day-to-day contact, Dr. Mcllvane will ensure that each of the program project's senior investigators receives regular feedback on their work from their colleagues and the program project's scientific advisory committee. Ms. Carol Curtin (Director of Communications, P01grant support requested: 5% in Year 1, as needed thereafter) has primary responsibility for facilitating communications within and external to the Shriver Center. In Year 1, she will be tasked with developing an informative, user- friendly website and addenda to brochures prepared by the MRDDRC's Clinical and Translational Research Core to assist in recruiting research participants appropriate to each of its constituent projects. Ms. Cynthia Kinahan (Department Administrator) and Ms. Donna Caira (Administrative Assistant) will provide general administrative support to the project. Their functions will be supported by the Shriver Center budget. Mr. Jeffery Baker is an on-