Center for Integrative Research on Childhood Leukemia and the Environment

描述（由申请人提供）：拟议中的新的儿童环境健康中心设在加州大学伯克利分校，旨在检查子宫内和早期生活暴露于家庭中存在的潜在致癌化学物质的影响（即，杀虫剂、烟草相关和表观遗传因素及其在儿童白血病发展中的相互作用。拟建的中心，简称为儿童白血病与环境跨学科研究中心（CIRCLE），包括三个研究项目和两个核心，如下：项目1（儿童白血病国际联盟研究）将确定暴露于最相关的时间段和儿童白血病亚型，并确定重要的遗传多态性，可以改变儿童白血病和父母烟草之间的关联吸烟或家庭农药暴露，通过汇集全球19项研究的数据;项目2（儿童白血病暴露评估）根据对室内灰尘和血液样本的分析，评估致癌物暴露，特别关注与烟草有关的污染物、多氯联苯和多溴二苯醚;项目3（产前暴露，DNA甲基化，和儿童白血病）将提供一个更清楚的了解父母吸烟，农药，多氯联苯，使用新生儿血液研究儿童白血病中的多溴联苯醚暴露和DNA甲基化模式。研究翻译和社区外展核心（RTCO核心）将向对儿童白血病病因学有共同兴趣的各种受众传播每个项目的研究结果。核心A的主要目标是：1）监督、协调和整合中心活动; 2）科学领导; 3）集中数据管理支持。核心A将建立和管理内部和外部咨询委员会;任命并与两名儿科健康专家合作，并支持中心结构内新的初级学院级研究人员的研究职业发展。核心A将在儿科健康专家的协助下，通过RTCO核心协调社区参与。

Description (provided by applicant): The proposed new Children's Environmental Health Center based at the University of California, Berkeley is designed to examine the effects of in utero and early life exposure to potentially carcinogenic chemicals present in homes (i.e., pesticides, tobacco-related and epigenetic factors and their interplay in the development of childhood leukemia. The proposed Center, referred to as Center for Interdisciplinary Research on Childhood Leukemia and the Environment (CIRCLE) includes three Research Projects and two Cores as follows: Project 1 (Childhood Leukemia International Consortium Studies) will identify the exposures to the most relevant time periods and childhood leukemia subtypes and identify important genetic polymorphisms that can modify the association between childhood leukemia and parental tobacco smoking or home pesticide exposure by pooling data from 19 studies worldwide; Project 2 (Exposure Assessment for Childhood Leukemia) y\/ill assess carcinogen exposures, based upon analysis of house dust and blood specimens, with special interest in tobacco-related contaminants, PCBs, and PBDEs; Project 3 (Prenatal exposures, DNA Methylation, & Childhood Leukemia) will provide a clearer understanding of the association between parental smoking, pesticides, PCBs, PBDEs exposures and DNA methylation patterns in childhood leukemia, using neonatal bloods. The Research Translation and Community Outreach Core (RTCO Core) will disseminate findings from each Project to various audiences with common interest in the etiology of childhood leukemia. The main objectives of Core A are to provide 1) oversight, coordination, and integration of Center activities; 2) scientific leadership; and 3) centralized data management support. Core A will establish and manage Internal and External Advisory Committees; appoint and collaborate with two Pediatric Health Specialists, and support the research career development of new, junior faculty-level investigators within the structure of the Center. Core A will coordinate Community Engagement through the RTCO Core, assisted by the pediatric Health Specialists.