CONTE CENTER

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 这一项目（Conte赠款的最后一次五年延期）在本报告所述期间结束。它资助了三项研究，这些研究利用了Conte赠款初始资助期间产生的应激和对照非人灵长类动物队列。研究1考察了早期压力对随后认知能力的影响，重点是陈述性和非陈述性记忆功能。研究2着眼于早期压力对情绪行为发展的影响，重点是恐惧和焦虑，以及大脑葡萄糖代谢的变化。研究3询问早期压力是否会导致比对照组猴子更快地获得可卡因自我管理，以及与对照组猴子相比，是否有更多的抵抗灭绝。这些研究使用结构和/或功能性脑成像来阐明行为变化与大脑变化之间的关系，并检查神经化学评估以阐明由于早期生活压力导致的行为变化与大脑化学之间的关系。研究1和2使用相同的猴子组，研究3使用单独的一组。由于孔蒂中心的赠款资金已经结束，动物被重新分配到一个新的挑战赠款和补充奖资助的项目，这将使我们能够继续调查早期生活压力的影响。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. This project (which was the final five-year renewal of the Conte grant) ended during the current period. It funded three studies that utilized the cohorts of stressed and control nonhuman primates generated during the initial funding period of the Conte grant. Study 1 examined the effects of early stress on subsequent cognitive abilities, with an emphasis on declarative and non-declarative memory functions. Study 2 looked at the effects of early stress on the development of emotional behavior, with an emphasis on fear and anxiety, and changes in cerebral glucose metabolism. Study 3 asked whether early stress results in acquiring cocaine self-administration more rapidly than control monkeys, and whether there is more resistance to extinction compared to control monkeys. The studies used structural and/or functional brain imaging to clarify the relationship between behavioral changes and changes in brain, and examined neurochemical assessments to clarify the relation between behavioral changes and brain chemistry due to early life stress. Studies 1 and 2 used the same groups of monkeys, and Study 3 used a separate group. Because the Conte Center grant funding has ended, the animals were reassigned to projects funded by a new Challenge Grant and Supplement awards that will allow us to continue investigations into the effects of early life stress.