EARLY LIFE STRESS IN NON HUMAN PRIMATES AND HUMANS

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 在报告期间，患有创伤后应激障碍的受试者未能抑制恐惧，这与创伤后应激障碍受试者基线和地塞米松治疗后的ACTH相关。这些结果表明，恐惧抑制受损和HPA反馈的相关变化可能反映了创伤后应激障碍受试者的杏仁核过度活动。 资金来源：这笔赠款现已终止。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. During the reporting period, subjects with PTSD failed to inhibit fear and this was correlated with baseline and post-dexamethsone ACTH in PTSD subjects. These results suggest that impaired fear inhibition and associated alterations in HPA feedback may reflect amygdala hyperactivity in subjects with PTSD. FUNDING SOURCE: This grant has now terminated.