EARLY LIFE STRESS IN NON-HUMAN PRIMATES AND HUMANS

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 在本报告所述期间，我们在其他工作中发现，创伤后应激障碍患者没有表现出正常的条件性抑制，这意味着我们对创伤后应激障碍的核心症状之一，即缺乏安全感，有了一个客观的衡量标准。我们在Yerkes建立了恒河猴AX+、BX-，并在3只对照猴和1只母系分离的猕猴中发现了良好的安全信号学习。在另外两只被分开的猴子中，他们没有表现出抑制性学习。这项工作现在将在另外34只猴子身上继续进行，这项工作是由挑战基金资助的，为此我聘请了一名新的非人类灵长类技术员来做这项工作。她现在已经完成了对另外12只猴子的测试，并几乎完成了对另外6只猴子的测试。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. During the reporting period, in other work we found that patients with PTSD do not show normal conditioned inhibition which means we have an objective measure of one of the core symptoms of PTSD, namely the inability to feel safe. We have set up the AX+, BX- in rhesus monkeys at Yerkes and have found good safety signal learning in 3 control and 1 maternally separated monkeys. In the other two separated monkeys they failed show inhibitory learning. This work will now continue in 34 more monkeys funded by a Challenge grant for which I hired a new non-human primate technician, to do this work. She has now completed testing on 12 more monkeys and is almost done with another 6 monkeys.