University of Kansas Alzheimer's Disease Core Center

这是来自堪萨斯大学(KU)研究人员的阿尔茨海默病核心中心(ADCC)的申请。在过去的五年中，KU团队开发了举办ADCC所需的基础设施。阿尔茨海默病(AD)的纵向特征和年龄匹配的对照队列已经建立，这些队列支持了许多研究项目。我们的研究队列已经按照统一数据集(UDS)指南进行了神经心理学表征，并在专门研究的神经成像中心进行了神经成像。每一步都是结合专家统计支助和数据库管理投入进行规划的。精心策划的面向非专业人群和当地医疗保健专业人员的外联活动促进了受试者的招募和保留，并提高了我们在堪萨斯城(KC)大都市区的AD研究计划的知名度，堪萨斯城都会区是美国第29大大都市区。 KU ADCC由NIA授权的五个ADCC核心、一个神经成像核心和一个线粒体基因组和代谢核心组成。这一基础设施帮助我们实现了我们的主要目标，即有效和全面地支持KU的AD和AD相关研究。为此，KU ADCC服务已经为KU的AD研究组合注入了活力，我们目前维持着一系列得到支持的研究项目组合。KU ADCC的第二个目标是提供先进的服务，以支持和促进突破性的AD、AD相关和脑老化代谢研究。我们的专业知识和我们提供的高度集成的跨学科服务将帮助AD研究领域定义健康、新陈代谢和线粒体如何独立和共同影响AD的进展和结果。我们相信，将我们的专业知识融入ADC系统将证明是实用和有价值的，将加强现有的ADC系统，并推动AD研究领域的发展。

This Is an Alzheimer's Disease Core Center (ADCC) application from investigators at the University of Kansas (KU). Over the past five years the KU team has developed the infrastructure needed to host an ADCC. Longitudinally characterized Alzheimer's disease (AD) and age-matched control cohorts have been established and these cohorts have supported numerous research projects. Our research cohorts have been characterized neuropsychologically per Uniform Data Set (UDS) guidelines and neuroimaged at a research-dedicated neuroimaging Center. Every step has been planned in conjunction with expert statistical support and database management input. Carefully orchestrated outreach to the lay population and local healthcare professionals has facilitated subject recruitment, retention, and raised awareness of our AD research program throughout the Kansas City (KC) metro area, the 29th largest metro area in the USA. The KU ADCC consists of the five NIA-mandated ADCC cores, a Neuroimaging Core, and a Mitochondrial Genomics and Metabolism Core. This infrastructure helps us pursue our principal aim of effectively and comprehensively supporting AD and AD-related research at KU. To this end KU ADCC services have already invigorated KU's AD research portfolio and we currently maintain a diverse portfolio of supported research projects. A second aim of the KU ADCC is to provide advanced services that enable and facilitate ground-breaking AD, AD-related, and brain aging metabolism research. Our expertise and the highly integrated, Inter-disciplinary services we provide will help the AD research field define how fitness, metabolism, and mitochondria independently and collectively influence progression and outcome in AD. We are confident that incorporating our expertise within the ADC system will prove both practical and valuable, strengthen the existing ADC system, and advance the AD research field.