CLINICAL TRIAL: SAFETY OF REPETITIVE TMS IN CHRONIC SUBCORTICAL STROKE

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 主要介绍：这项研究将评估重复经颅磁刺激(RTMS)，它涉及到传递TMS脉冲的速度比目前UCI批准的单脉冲TMS方法更快。该技术在按以下描述使用时具有完美的安全记录，并且如果在这里未考虑的较高设置下使用，则具有小的风险。 目前的方案由哈佛医学院的Alvaro Pascual-Leone博士担任小组PI，他在rTMS方面拥有丰富的经验。重点是，目前研究的所有方面都是与该方法的一位世界专家合作设计的，这应该会增加人们对确保安全的努力的准确性的信心。 在研究的第一部分，副作用风险最低的患者将接受一次rTMS疗程。如果第一部分被发现是安全的，第二部分将开始，这将提供一个单独的队列患者，在5周内接受10次rTMS治疗。 健康对照组将只在功能磁共振成像(FMRI)方法方面进行研究。本研究中的对照受试者将不会接受rTMS。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Main introduction: This study will evaluate repetitive transcranial magnetic stimulation (rTMS), which involves delivering TMS pulses faster than with the single pulse TMS methods currently approved at UCI. The technique has a perfect safety record when used as described below, and can have small risks if used at higher settings not considered herein. The current protocol has Dr. Alvaro Pascual-Leone of Harvard Medical School as the sub-PI, who has extensive experience in rTMS. The point is that all aspects of the current study were devised in collaboration with one of the world experts in the method, which should increase confidence in the accuracy of efforts to insure safety. In part 1 of the study, patients at lowest risk of side effects will receive a single rTMS session. If part 1 is found to be safe, part 2 will begin, which will provide a separate cohort of patients with 10 rTMS sessions over 5 weeks. Healthy controls will be studied only with respect to functional MRI (fMRI) methods. Control subjects in the current study will not receive rTMS.