Genomics Alcohol Research Core

描述（由申请人提供）：以下拨款申请是为了响应RFA-OD-09-005（恢复法案有限竞争：支持新的教师招聘，通过生物医学研究核心中心加强研究资源[P30]）而提交的。我们相信，该应用程序是响应RFA，我们寻求雇用，提供适当的启动包，并为新的独立调查人员开发试点研究项目，以增强和扩大OHSU的多学科研究人员社区的目标专注于与NIH相关的生物医学研究领域。该P30专注于生物信息学核心，目标是招募对酒精和药物滥用感兴趣的个人，以及对小鼠和非人类灵长类动物基因组学感兴趣的个人。对酒精和药物滥用的强调与申请部门的兴趣和资助组合-行为神经科学一致。因此，我们认为申请最好直接向国家酒精滥用和酒精中毒研究所（NIAAA）提出。本申请的主要合作伙伴，俄勒冈州国家灵长类动物研究中心（ONPRC）支持这一对齐;在这里，我们注意到相对较新的联合招聘（行为神经科学和ONPRC）凯西·格兰特博士，一位灵长类动物酗酒模型的领先专家和本申请的合作者。然而，我们（行为神经科学和ONPRC）认为通过P30机制招募的个体在OHSU开发生物信息资源方面也发挥着更大的作用。P30的大部分资金将用于帮助招聘初级教师和开发一个试点研究项目。成功的申请人（S）将被任命为行为神经科学系的助理教授（终身制），并在ONPRC担任科学家，在分子和医学遗传学和医学信息学和临床流行病学部门联合任命。成功的申请人（S）的核心内的位置将是个人（S）在我们称为“系统生物信息学”领域的专业知识。使用这个术语的目的是，我们将招募一个不仅具有分析技能的人，以有效地利用新兴技术，如mRNAseq或ChiPseq，而且对解决与中心相关的问题感兴趣。 公共卫生相关性：由P30机制支持的核心中心将用于招募新的教师，从生物学角度研究酒精滥用和酒精中毒。这项研究最初将涉及使用复杂的分析方法来研究受长期酒精暴露影响的大脑和其他组织中的基因表达。目的是检测潜在的病理机制。

DESCRIPTION (provided by applicant): The following grant application is submitted in response to RFA-OD-09-005 (Recovery Act Limited Competition: Supporting New Faculty Recruitment to Enhance Research Resources through Biomedical Research Core Centers [P30]). We believe that the application is responsive to the RFA In that we seek to hire, provide appropriate start-up packages and develop pilot research projects for newly-independent investigators, with the goal of augmenting and expanding OHSU's community of multidisciplinary researchers focusing on areas of biomedical research relevant to NIH. This P30 focuses on a Bioinformatics Core with the goal of recruiting individual(s) with interests in alcohol and drug abuse coupled with interests in mouse and non-human primate genomics. The emphasis on alcohol and drug abuse aligns with the interests and grant portfolio of the applicant department - Behavioral Neuroscience. Thus, we feel the application is best directed to the National Institute on Alcohol Abuse and Alcoholism (NIAAA). The primary partner in this application, the Oregon National Primate Research Center (ONPRC) supports this alignment; here we note the relatively recent joint hiring (Behavioral Neuroscience and the ONPRC) of Dr Kathy Grant, a leading expert on primate models of alcohol abuse and a collaborator on this application. However, we (Behavioral Neuroscience and the ONPRC) view the indlvidual(s) recruited through the P30 mechanism as also having a larger role in developing bioinformatic resources at OHSU. The bulk of the P30 funding will be used to help recruit junior faculty and to develop a pilot research program. The successful applicant(s) will be appointed as an Assistant Professor in the Department of Behavioral Neuroscience (tenure track) and as a Staff Scientist at the ONPRC, with joint appointments in the Departments of Molecular & Medical Genetics and Medical Informatics and Clinical Epidemiology. The successful applicant(s) for the position within the Core will be individual(s) with expertise in a field we have termed "systems bioinformatics". The intent of using this term is that we will recruit an individual not only with the analytical skills to effectively utilize emerging technologies such as mRNAseq or ChiPseq but also with interests in solving problems related to the Center. PUBLIC HEALTH RELEVANCE: The Core Center supported by the P30 mechanism will be used to recruit new faculty to study from a biological perspective, alcohol abuse and alcoholism. The research will involve initially the use of sophisticated analytical approaches to study gene expression in brain and other tissues affected by chronic alcohol exposure. The goal is to detect the underlying pathological mechanisms.