CEREBELLUM AND VISUALLY GUIDED ARM MOVEMENTS

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 本申请涉及我们目前NIH资助的继续研究小脑中与视觉引导运动相关的运动信号的性质。这些研究表明，位置，速度和速度信息是如何编码在小脑浦肯野细胞的放电，手动跟踪是由离散的亚基组成的速度脉冲高度相关的小脑浦肯野细胞的放电。我们正在研究运动错误的处理，以及如何使用错误信息来控制运动的即时和长期变化（即运动学习）。 本研究的前两个特定目的扩展了我们对小脑是手臂逆动力学模型的部位这一假设的检验。特定目的1通过检查在圆形跟踪任务期间间位神经元和齿状神经元的放电来检验小脑核是逆动力学模型的输出阶段这一假设，在圆形跟踪任务中，在不同大小的粘性和弹性力场被施加到小脑核中。手具体目标2检查浦肯野细胞放电是否与力控制或力反馈用于执行任务时的逆动力学模型的输出一致。特定目的3-5检验浦肯野细胞简单棘波放电是预测即将到来的手臂运动学的手臂前向内部模型的输出的假设。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This application is related to the continuation of our present NIH grant examining the nature of the movement signals in the cerebellum associated with visually-guided movements. These studies have shown how position, velocity and speed information are encoded in the discharge of cerebellar Purkinje cells and that manual tracking is composed of discrete subunits consisting of speed pulses highly correlated with the discharge of cerebellar Purkinje cells. We are investigating the processing of movement errors and how that error information is used to control movements both immediately and for long-term changes (i.e. motor learning). The first two Specific Aims of this study expand our testing of the hypothesis that the cerebellum is the site of an inverse dynamics model of the arm. Specific Aim 1 tests the hypothesis that the cerebellar nuclei are the output stage of an inverse dynamics model by examining the firing of interpositus and dentate neurons during a circular tracking task in which viscous and elastic force fields at varying magnitudes are applied to the hand. Specific Aim 2 examines whether Purkinje cell discharge is consistent with the output of an inverse dynamics model when force control or force feedback is used to perform the task. Specific Aims 3-5 test the hypothesis that Purkinje cell simple spike discharge is the output of a forward internal model of the arm that predicts the upcoming arm kinematics.