ASSESSMENT OF BRIAN IRON & NEURONAL INTEGRITY USING NOVEL T1P & T2P MRI

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 我们在这个项目中的目标是：A)利用单侧6-羟基多巴胺(6-OHDA)PD小鼠模型(纹状体内注射6-OHDA/L)建立T1？MRI方法的预测/判别能力；B)研究T1？MRI定位识别无晶状体小鼠受神经元丢失影响的脑区的能力，并探讨T2？与组织铁负荷的定量关系；C)确定无晶状体小鼠SNC、SNR、VTA和纹状体的T1与神经元密度、T2与铁负荷之间的定量关系。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Our goals in this project are: A) to establish the predictive/discriminatory ability of the T1¿ MRI method using a unilateral 6-hydroxydopamine (6-OHDA) PD mouse model (intrastriatal injection of 2 ¿g 6-OHDA/¿L); B) To investigate the ability of T1¿ MRI mapping to recognize regions of the brain affected by neuronal loss in aphakia mice, and to investigate the quantitative relationship between T2¿ and iron loading in tissue; C) To identify the quantitative relationship between the T1¿ measurements and neuronal density, and between T2¿ and iron loading in the aphakia mouse in the SNc, SNr, VTA and striatum.