UNDERGRADUATE AND MEDICAL STUDENT RESEARCH PROJECTS

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 在资源主任和工作人员的指导下，学生参加了波士顿大学本科生研究机会计划和2009-10学年医学生研究计划下的MS资源研究。波士顿大学化学系学生在年度本科生研究研讨会上介绍他们的工作。来自其他机构的本科生也有资格在资源进行研究。 先生Nikhil Madhusudhan是一名化学专业的学生，于2007年秋季加入该资源。他选择参加BU是基于在资源/CPC进行研究的机会。他正在从事的项目涉及电泳蛋白分离作为我们的蛋白质森林设备的β测试的一部分，并使用该设备在他的淀粉样蛋白转甲状腺素蛋白的氧化翻译后修饰的研究。 先生Paul Romesser在资源合作者Gerald Denis的指导下工作了几年。他一直密切参与Brd 2复合物的蛋白质组学研究。他在2005年由Costello教授和Mann教授组织的Keystone会议和2007年ASMS会议上展示了他的研究海报。2006年夏天，Romesser先生获得了特别资助，使他能够在资源和CPC全职工作。Romesser先生于2006年秋季开始在BUSM进行医学研究，但继续在Resource进行研究。在本报告所述期间发表了一份描述其结果的新手稿。在这个学年，他在国家卫生研究院进行了第二年的研究，根据霍华德休斯基金会计划。 教授Zaia在该项目中聘请了一组计算机科学专业的本科生来开发支持聚糖分析的软件。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Guided by the Resource Directors and staff, students participated in MS Resource research under the Boston University Undergraduate Research Opportunities Program and programs for medical student research in the 2009-10 academic year. Boston University Chemistry Dept. students make presentations on their work at the annual Undergraduate Research Symposium. Undergraduates from other institutions are also eligible to conduct research at the Resource. Mr. Nikhil Madhusudhan is a chemistry major and joined the Resource in fall 2007. His choice to attend BU was strongly based on the opportunity to perform researdh at the Resource/CPC. He is working on projects that involve electrophoretic protein separation as part of our beta-test of the Protein Forest device and is using this device in his investigation of oxidative post-translational modifications of the amyloid protein transthyretin. Mr. Paul Romesser has worked under the direction of Resource collaborator Gerald Denis for several years. He has been closely involved in proteomics studies of Brd2 complexes. He presented poster on his research at the 2005 Keystone Conference organized by Prof. Costello and Prof. Mann and at the 2007 ASMS meeting. For the summer of 2006, Mr. Romesser received special funding to allow him to work full time at the Resource and CPC. Mr. Romesser began his medical studies at BUSM in Fall 2006 but has continued to carry out research at the Resource. A new manuscript describing his results was published during this reporting period. During this academic year he is performing a second year of research at NIH, under a Howard Hughes Foundation program. Prof. Zaia has engaged a group of undergraduate students in the Computer Science program in the project to develop software to support glycan analysis.