NUTRIENT RESTRICTION AND DEVELOPMENTAL PROGRAMMING

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 本文提出的研究目的是开始了解在啮齿动物、豚鼠和绵羊模型中展示的关于营养限制对具有良好特征的灵长类动物模型的终生健康影响的令人信服的数据的适用性，从而帮助证明临床人类相关性。从妊娠30天(DG)开始，怀孕的雌性狒狒将被随机喂养(CTR)或70%的CTR饮食(MNR)，直到后代在出生后9个月断奶。对几个不同物种的广泛研究，但不是在非人类灵长类动物中的研究表明，由于母体营养限制而导致的发育过程中胎儿环境的变化对健康有长期的影响。其中包括后代易患慢性疾病，这些疾病会缩短寿命，并极大地损害生活质量，如高血压、中风和成人糖尿病。观察到我们在子宫和新生儿早期经历的环境质量对终身健康有影响的观察被称为“发展规划”，是对我们社会所有成员至关重要的生物医学调查领域。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The purpose of the studies proposed herein is to begin to understand the applicability of the compelling data on the effects of nutrient restriction demonstrated in rodent, guinea pig and sheep models on the lifetime health of a well-characterized primate model, thus helping to demonstrate clinical human relevance. Starting at 30 days of gestation (dG), pregnant female baboons will be fed either ad lib (CTR) or 70% of CTR diet (MNR) until offspring weaning at 9 months post-natal. Extensive studies in several different species, but not in non-human primates, show that alterations of the fetal environment during development by maternal nutrient restriction have long-term consequences for health. Among these are offspring predisposition to chronic conditions that decrease lifespan and greatly impair the quality of life such as hypertension, stroke and adult - onset diabetes. The observation that the quality of the environment we experience in the womb and during the early neonatal period has implications for life-long health is called "developmental programming" and is an area of biomedical investigation of critical importance to all members of our society.