MOVEMENT DISORDERS AND EYE MOVEMENTS

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 目的：了解高阶加工或认知对自主运动控制的影响。 由于自愿行动的执行通常涉及目标选择、学习、记忆、计划和期望等过程，运动系统非常适合研究这些过程。我们研究导致眼球运动执行的神经元过程，特别是那些导致视线快速变化的眼球运动--扫视。我们有一种多技术方法来研究这些过程。首先，当受试者执行旨在利用认知过程的眼动任务时，我们记录单个神经元的电活动。其次，我们激活或停用大脑的特定区域，以产生行为或干扰正在进行的行为和神经处理。最后，由于某些大脑区域的损伤会导致严重的临床疾病，如帕金森氏症和亨廷顿病，我们研究了健康和疾病受试者的眼球运动，以加深我们对这些结构在认知中所起的作用以及在产生这些疾病的衰弱效应方面的理解。 这项研究使用了WNPRC动物服务中心。 出版物： 金·B，马萨诸塞州巴索。理解动作选择的概率策略。J神经科。2010年2月10日；30(6)：2340-55。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Objective: To understand how higher order processes or cognition contribute to the control of voluntary movement. Because the execution of voluntary actions usually involves processes such as target selection, learning, memory, planning and expectation, motor systems are well suited for study of these processes. We investigate neuronal processes leading up to the execution of movements of the eyes, in particular, those eye movements that lead to rapid changes in the line of sight - saccades. We have a multi-technique approach to the study of these processes. First, we record electrical activity of single neurons while the subjects perform eye movement tasks designed to tap into cognitive processes. Second, we activate or inactivate particular regions of the brain to produce behaviors or interfere with ongoing behaviors and neural processing. Finally, because damage to certain brain regions produces profound clinical disorders such as Parkinson's disease and Huntington's disease, we study eye movements of both healthy and diseased human subjects to further our understanding of the role these structures play in both cognition and in producing the debilitating effects of these disorders. This research used WNPRC Animal Services. PUBLICATION: Kim B, Basso MA. A probabilistic strategy for understanding action selection. J Neurosci. 2010 Feb 10;30(6):2340-55.