International Conference on Dental and Craniofacial Stem Cells

描述（由申请人提供）：在过去二十年中，已从牙齿、口腔和颅面（DOC）组织中分离并鉴定出具有干/祖细胞特性的细胞。在牙科和颅面研究史上，这是第一次有可能操纵分化成面部和口腔中许多组织的细胞。牙科和颅面重建的实践依赖于来源于DOC干/祖细胞的组织，并且随着时间的推移，将通过基于对DOC干/祖细胞的理解的转化和治疗方法的发展而转变。然而，我们现有的知识DOC干/祖细胞是零碎的最好的。DOC干细胞来源于神经嵴来源的间充质细胞，具有独特的特性，使其区别于通常研究的骨髓来源的间充质细胞。大约9年前发现后，关于DOC干/祖细胞的科学文献数量呈指数级增长。令人担忧的是，DOC干/祖细胞正在临床前模型和患者中输注，对其行为只有零散的了解。因此，我们建议第一次国际会议致力于牙科，口腔和颅面干细胞/祖细胞，不仅讨论和传播目前的知识DOC干细胞/祖细胞的生物学，而且其推定的应用在口腔和面部组织的再生。该提案的总体目标是设计和计划第一届国际牙科和颅面干细胞会议（ICDCSC），该会议将促进DOC干/祖细胞研究和翻译相关知识的传播和未来方向的确定。与会者之间的广泛共识将构成建立科学指南的基础，包括DOC干/祖细胞自我更新、分化和翻译的严格分子和功能测定。本次会议计划于2010年10月在纽约市举行，纽约市有直飞航班往返于许多美国和国际城市，并在一个有利于多学科讨论DOC干/祖细胞的科学和治疗潜力的环境中举行。该会议将由牙科，生物技术和制药行业的科学家，临床医生，政府官员和行业代表广泛参加。我们不仅收到了科学家的强烈反应，也收到了政府官员和牙科，生物技术和制药行业的强烈反应。本次会议的成果将发表在高影响力的干细胞或再生医学杂志上，并作为DOC干/祖细胞生物学和翻译动态领域的工作和不断发展的指导方针。 公共卫生相关性：在过去的十年及以后，具有干/祖细胞特性的出生后细胞已经从牙齿、口腔和颅面（DOC）组织中分离和鉴定。在牙科和颅面研究的历史上，我们第一次有能力操纵那些分化成面部和口腔中许多组织或器官的细胞。预计随着时间的推移，牙科和颅面重建的实践将通过依赖于对DOC干细胞的理解的转化和治疗方法的发展而转变。该提案的总体目标是设计和计划第一届国际牙科和颅面干细胞会议（ICDCSC），该会议将促进DOC干/祖细胞研究和翻译相关知识的传播和未来方向的确定。该会议将由牙科，生物技术和制药行业的科学家，临床医生，政府官员和行业代表广泛参加。本次会议的成果将发表在高影响力的干细胞或再生医学杂志上，并作为DOC干/祖细胞生物学和翻译动态领域的工作和不断发展的指导方针。

DESCRIPTION (provided by applicant): In the past two decades, cells with properties of stem/progenitor cells have been isolated and identified from dental, oral and craniofacial (DOC) tissues. For the first time in the history of dental and craniofacial research, it is possible to manipulate the very cells that differentiate into many of the tissues in the face and oral cavity. The practice of dentistry and craniofacial reconstruction rests on tissues that derived from DOC stem/progenitor cells, and will be transformed, over time, by the development of translational and therapeutic approaches based on the understanding of DOC stem/progenitor cells. However, our existing knowledge of DOC stem/progenitor cells is fragmentary at best. DOC stem cells originate from neural crest-derived mesenchyme, and possess unique characteristics that distinguish them from commonly studied bone-marrow derived mesenchymal cells. Upon their discovery about 9 years ago, the volume of scientific literature on DOC stem/progenitor cells has grown exponentially. Alarmingly, DOC stem/progenitor cells are being infused in preclinical models and patients with only fragmented knowledge of their behavior. Accordingly, we propose the first international conference dedicated to dental, oral and craniofacial stem/progenitor cells, not only to discuss and disseminate current knowledge on the biology of DOC stem/progenitor cells, but also their putative applications in the regeneration of tissues of the oral cavity and the face. The overall goal of this proposal is to design and plan the first International Conference on Dental and Craniofacial Stem Cells (ICDCSC) in a forum that promotes the dissemination of knowledge and identification of future directions in relation to DOC stem/progenitor cell research and translation. Broad consensus among conference participants will form the basis for establishing scientific guidelines, including rigorous molecular and functional assays for self renewal, differentiation and translation of DOC stem/progenitor cells. This conference is being planned to take place in October, 2010 in New York City, which has direct flights to/from numerous U.S. and international cities, and in a setting that is conducive for multi-disciplinary discussion of the science and therapeutic potential of DOC stem/progenitor cells. The conference will be widely attended by scientists, clinicians, government officials, and industry representatives in dental, biotechnology and pharmaceutical industries. We have received overwhelmingly robust response from not only scientists, but also government officials and dental, biotechnology and pharmaceutical industry. The outcome of this conference will be published in a high impact stem cell or regenerative medicine journal and serve as working and evolving guidelines for the dynamic field of the biology and translation of DOC stem/progenitor cells. PUBLIC HEALTH RELEVANCE: In the past decade and beyond, postnatal cells with properties of stem/progenitor cells have been isolated and identified from dental, oral and craniofacial (DOC) tissues. For the first time in the history of dental and craniofacial research, we have the ability to manipulate the very cells that differentiate into many tissue or organ in the face and oral cavity. It is projected that the practice of dentistry and craniofacial reconstruction will be transformed, over time, by the development of translational and therapeutic approaches that rely on the understanding of DOC stem cells. The overall goal of this proposal is to design and plan the first International Conference on Dental and Craniofacial Stem Cells (ICDCSC) in a forum that promotes the dissemination of knowledge and identification of future directions in relation to DOC stem/progenitor cell research and translation. The conference will be widely attended by scientists, clinicians, government officials, and industry representatives in dental, biotechnology and pharmaceutical industries. The outcome of this conference will be published in a high impact stem cell or regenerative medicine journal and serve as working and evolving guidelines for the dynamic field of the biology and translation of DOC stem/progenitor cells.