MENTORING IN CARDIOVASCULAR BIOLOGY

本次COBRE续期申请的总体目标是通过支持专题、多学科、多机构项目和增强的基础设施能力，继续扩大和改善路易斯安那州立大学健康科学中心-新奥尔良（LSUHSC-NO）的心血管研究，以此在上一个资助期内取得的成功为基础。通过这笔拨款的初始资金，LSUHSC-NO建立了一支有才华的心血管研究人员队伍，他们对心血管病理生理学基础的分子机制的基本理解做出了重大贡献。通过强有力的领导，承诺的指导，与外部咨询委员会和最先进的核心设施的互动关系，我们已经实现了9个目标教师中的8个的创纪录的职业发展，5个NIH RO1资助，2个NIH R21资助，4个AHA基本资助和2个科学家发展资助，以及2个教师赞助的前和博士后研究员资助奖（AHA和国防部）。

The overall objectives for this COBRE renewal application is to build upon the successes accomplished during the previous funding period by continuing to expand and improve Cardiovascular Research at the Louisiana State University Health Sciences center-New Orleans (LSUHSC-NO) through support of thematic, multi-disciplinary and multi-institutional programs and enhanced infrastructure capabilities. The initial funding through this grant established a cadre of talented cardiovascular researchers at LSUHSC-NO that have made significant contributions to the basic understanding of molecular mechanisms that underlie cardiovascular pathophysiology. Through the strong leadership, committed mentoring, an interactive relationship with the External Advisory Committee and state-of-the-art Core facilities, we have achieved a record career advancement of 8 of 9 targeted faculty, 5 NIH RO1 grants, 2 NIH R21 grants, 4 AHA Basic Grant- In-Aid and 2 Scientist Development Grants, and 2 faculty sponsored Pre- and Postdoctoral Fellow Grant awards (AHA and Department of Defense). The renewal builds upon strength of the original program to achieve a more ambitious goal of an established Cardiovascular Center of Excellence though program grant applications focusing on translational cardiovascular research. To this end, we are requesting support in this renewal application for the research programs of 7-8 junior and promising developing investigators who will receive tailored one-on-one and team mentoring, the support for 3 scientific core facilities and 1 administrative core that has strong business administration and management, faculty development, and program development components. The Specific Aims of this COBRE renewal are: Aim 1. To expand the critical mass of NIH funded investigators at the LSUHSC-NO with research programs in the area of cardiovascular disease progression. Aim 2. To enhance the infrastructure and support of existing and new core facilities that will continue to provide state-of-the-art research resources to promising junior and established investigators. Aim 3. To provide an exit strategy that will complete the intellectual foundation and technological platform to transition from a COBRE supported project to a nationally recognized, interdisciplinary translational Cardiovascular Center of Excellence. This proposal will build effective scientific collaborations between basic and clinician scientists for PPG, SCCOR and CTSA funding that will sustain the Cardiovascular Center beyond completion of COBRE funding.