CHRONOBIOLOGIC MARKERS FOR LAB MEDICINE AND THERAPY

A.具体目标 最初的目标没有改变。研究继续侧重于三个主要的相互关联的 主题，即通过生理监测进行风险检测来预防中风， 通过BIOCOS进行全球监测（研究生物圈和COSmos对生物群的影响），以及 从而绘制大约每周一次、半周一次（circaseptan和circasemiseptan）和其他成分的图谱 在超过10个数量级的光谱中。7天/24小时血压和心脏监测 率被强调用于识别疾病风险综合征，不仅涉及平均值的改变， 值，但在血压和心率的变异性，包括他们的昼夜节律和昼夜节律 模式.所有参与研究中心继续进行监测。特别是，日本浦宿和土佐的公民， 今年获奖者被邀请演讲的地方，正在进行筛选， 通过问卷调查[59-62]评估的生活质量指数，以及正在获得的结果。 研究了非光太阳对生理和病理的影响。新发现 包括证明在新的和更新的血液记录中检测到的约1.3年的成分， 压力和心率的变化跨度长达40年，与报道的太阳风速度的1.3年周期相匹配 约翰D。理查森[40，41，54，91，138，158，164，173]。一个大约1.3年的组成部分， 在明尼苏达州和其他几个州的心源性猝死（ICD 10，146.1）发生率中观察到 在没有一年期同步组成部分的情况下，地理位置。新的不透光的映射 以及已知的光周期继续[87，127，133，153]。这项工作导致了新的 时间组学领域和时间组学地图集的开始，这是未来几年要追求的主要主题。 年 现在，根据7天/24小时的 每隔30分钟测量一次血压和心率。数据库摘要 t方括号内的数字指“获奖者出版物”项下所列的标题。 浦洲市（日本北海道）在抑郁症患者中显示出更明显的昼夜变化， 主题[59]。 总之，获奖者的活动有三个主要主题，即 1.开发新疾病风险综合征的治疗模式; 2.评估非光效应和光效应对生命形式的影响，包括日光和 地磁学对人体生理和病理的影响;这种低频分量的映射是 开始，奠定了时间组学的新领域; 3.在选定的物种中绘制时间序列图，重点是生物日的相对重要性 vs.生物周和跨年对日历年。

A. SPECIFIC AIMS The original aims have not been modified. Research continued with focus on three major inter-related topics, namely stroke prevention by risk detection via physiological monitoring, the implementation of such monitoring worldwide via BIOCOS (the study of effects of the BlOsphere and the COSmos on biota), and thereby the mapping of about-weekly, half-weekly (circaseptan and circasemiseptan) and other components in spectra covering over 10 orders of magnitude. The 7-day/24-hour monitoring of blood pressure and heart rate was emphasized for the identification of disease risk syndromes involving alterations not only in mean values but in the variability of blood pressure and heart rate, including their circadian and circaseptan patterns. Monitoring continued at all participating centers. In particular, citizens of Urausu and Tosa, Japan, where the awardee was invited to lecture this year, are being screened with additional focus on several indices of quality of life assessed by questionnaires [59-62]t and where outcomes are becoming available. The study of non-photic solar effects on physiology and pathology has been pursued. New findings include the demonstration of an about 1.3-year component detected in new and updated records of blood pressure and heart rate spanning up to 40 years, matching the 1.3-year cycle in solar wind speed reported by John D. Richardson [40, 41, 54, 91, 138, 158, 164, 173]. An about 1.3-year component has notably been observed in the incidence of sudden cardiac death (ICD10, 146.1) in Minnesota and in several other geographic locations, in the absence of a 1-year synchronized component. The mapping of new non-photic as well as of known photic cycles has continued [87, 127, 133, 153]. This work led to the birth of the new field of chronomics and the start of an atlas of chronomes, the major topic to be pursued in the next few years. About-weekly and half-weekly components are now routinely assessed from the 7-day/24-hour profiles of blood pressure and heart rate measured around the clock at 30-min intervals. Summaries of data bases in tNumbers in square brackets refer to titles listed under Publications by awardee. the city of Urausu (Hokkaido, Japan) revealed a more pronounced circaseptan variation among depressive subjects [59]. In summary, three major themes in the activities of the awardee were pursued, namely 1. the development of treatment modalities of new disease risk syndromes; 2. the assessment of non-photic as well as photic effects on life forms, including influences from helio- and geomagnetics on human physiology and pathology; the mapping of such low frequency components was started, underlying the new field of chronomics; and 3. the mapping of chronomes in selected species, with focus on the relative importance of the biological day vs. the biological week and of the transyear vs. the calendar year.