Molecular Analysis, Modeling and Correction of Skin Diseases

简介（由申请人提供）：申请建立科罗拉多大学丹佛分校皮肤病研究中心（UCD-SDRC）。该中心将强调理解人类自身免疫、炎症、发育、代谢和遗传性皮肤病的分子基础，并开发基因工程小鼠模型，在遗传和表型水平上模拟这些疾病。这些小鼠模型将用于开发新的治疗方法，如基于干细胞的治疗。该中心包括49名研究人员，其中15名来自皮肤科，34名来自UCD其他部门或与UCD合作的其他机构。这些研究人员的研究兴趣广泛：炎症和免疫、上皮生物学、黑素细胞生物学、再生医学和干细胞生物学、分子细胞和发育生物学、生物化学、药理学、微生物学和病毒学、遗传学和基因组学、组织修复、皮肤癌变和临床研究。这是一个丰富的基础和转化研究跨学科发现的平台。这一建议有四个具体目标：1。提供核心设施作为基础和转化研究的跨学科发现平台，管理核心，分子遗传分析核心，转基因和基因靶向核心，形态学和表型核心，以及流式细胞术核心；2组织一个强大的试点和可行性计划，以吸引新的研究者（年轻的，以及成熟的）进入皮肤和皮肤疾病的研究。该应用程序中包括六个新的P&F项目，以及一个选择未来项目的结构；3 .为UCD-SDRC组织一个充实计划；组建临床研究小组，以核心研究和P&F研究支持的基础研究发现为基础，促进转化研究项目的发展。UCD-SDRC的长期目标是通过协调和培养各种非常成功的基础科学和临床研究人员之间的多学科研究，培训和临床护理，为皮肤生物学，病理生物学和临床皮肤病学提供新方法和见解的机会。

DESCRIPTION (provided by applicant): This is a new proposal to establish the University of Colorado-Denver Skin Diseases Research Core Center (UCD-SDRC). This center will emphasize understanding the molecular basis of human autoimmune, inflammatory, developmental, metabolic and genetic skin diseases and development of genetically engineered mouse models which mimic these disorders at both the genetic and phenoty pic levels. These mouse models will be utilized for the development of new therapeutic approaches, such as stem cell-based treatments. This Center includes 49 investigators, 15 from within the Department of Dermatology and 34 from other UCD Departments or from other sites collaborating with UCD. The research interests of these investigators are broad: Inflammation and immunity, epithelial biology, melanocyte biology, regenerative medicine and stem cell biology, molecular cellular and developmental biology, biochemistry, pharmacology, microbiology and virology, genetics and genomics, tissue repair, cutaneous carcinogensis, and clinical research. This is a rich platform for interdisciplinary discovery in basic and translational research. This proposal has four Specific Aims: 1. To provide Core facilities as a platform for interdisciplinary discovery in basic and translational research, an Administrative Core, Molecular Genetic Analysis Core, Transgenic and Gene Targeting Core, Morphology and Phenotyping Core, and a Flow Cytometry Core: 2 To organize a robust Pilot and Feasibility program to attract new investigators (young, as well as, established) into research in the skin and skin disease. Six new P&F projects are included in this application, as well as a structure for selection of future projects; 3 To organize an Enrichment Program for the UCD-SDRC; 4 To assemble a Clinical Investigations Team to facilitate development of translational research projects based on the basic research discoveries supported by the cores and P&F studies. The long-term goal of the UCD-SDRC is to provide opportunities for novel approaches and insights into cutaneous biology, pathobiology and clinical dermatology through coordinating and nurturing multidisciplinary research, training, and clinical care among a variety of highly successful basic science and clinical investigators.