Training Grant in Genomic Analysis and Interpretation

有两种趋势极大地改变了生物医学研究培训的前景。首先是越来越强调多学科研究，要求研究人员既要在自己的特定专业领域有深度，又要有与不同领域的其他科学家建立新的联系和合作所需的广泛技能。第二是越来越多地使用复杂的统计和计算数据分析，特别是基因组数据。 数学和计算科学家必须彻底参与他们正在研究的问题的生物学问题，如果他们能够与同事交流并做出重要贡献的话。 拟议的计划将提供新的环境遗传学博士前和博士后培训，涵盖遗传学，分子和环境流行病学，统计遗传学，生物信息学和计算分子生物学等学科。研究人员建议建立在（南加州大学）南加州大学预防医学部在癌症和环境流行病学的历史实力，将他们的培训集中在解剖复杂的生物学途径，涉及基因-环境和基因-基因相互作用，这些问题是NIEHS环境基因组计划的核心。 研究人员还建议将这些基于凯克医学院的培训课程与位于大学公园校园的分子和计算生物学课程更紧密地结合起来，以提供与NHGRI人类基因组计划和国际单倍型作图（“HapMap”）项目相关的现代基因组学和生物信息学技术的培训。 这项建议的具体目标是为三名博士前科学家和两名博士后科学家提供多学科培训，以接受环境卫生与基因组学之间的专门培训。广泛的研究资源可用于支持研究癌症和其他疾病中的基因-环境和基因/基因相互作用。

Two trends have dramatically altered the landscape of training in biomedical research. The first is increasing emphasis on multidisciplinary research, requiring investigators to have both depth in their own particular area of expertise, as well as the breadth of skills required to form new liaisons and collaborations with other scientists in diverse fields. The second is the increasing use of sophisticated statistical and computational data analyses, especially of genomic data. Mathematical and computational scientists must be thoroughly engaged in the biological issues of the problems they are working on if they are to be able to communicate with their colleagues and make important contributions. The proposed program will offer new pre-and postdoctoral training in environmental genetics that spans the disciplines of genetic, molecular and environmental epidemiology, statistical genetics, bioinformatics and computational molecular biology. The investigators propose to build upon the historical strength of the (University of Southern California) USC Department of Preventive Medicine in cancer and environmental epidemiology to focus their training on dissecting complex biological pathways involving gene-environment and gene-gene interactions, issues that are central to the NIEHS Environmental Genome Project. The investigators also propose to integrate these training programs based at the Keck School of Medicine more closely with those in the Program in Molecular and Computational Biology located at the University Park Campus, in order to provide training in modern genomics and bioinformatics techniques that are relevant to the NHGRI Human Genome Project and International Haplotype Mapping ("HapMap") Project. The specific aims of this proposal are to provide multidisciplinary training for three pre-doctoral scientists and two postdoctoral scientists in specialized training at the interface between environmental health and genomics. Extensive research resources are available in support of studying gene-environment and gene/gene interactions in cancer and other diseases.