Genetics and Molecular Biology Parkinsonism

梅奥诊所的尤德尔帕金森病卓越研究中心是一个综合的多学科研究项目，由神经学家、神经心理学家、遗传学家、神经病理学家和基础科学家组成，研究“帕金森病的遗传学和分子生物学”。该中心利用梅奥诊所运动障碍科的临床优势，以及帕金森病（PD）和路易体痴呆（DLB）的纵向研究，作为研究项目中使用的临床材料，以及对PD研究的坚定机构承诺。尽管Udall团队成员拥有广泛的专业知识和科学背景，但所提出的研究具有高度的协同作用。团队的每一个成员都为这项任务带来了独特的知识和技能，我们的团结比各个部分的总和更伟大。提议的工作建立在高度成功和富有成效的核心之上，这些核心已经一起工作了十多年。临床，遗传和病理资源是少数中心相媲美。梅奥尤德尔中心是尤德尔中心项目的独特补充。我们尤德尔中心的成功建立在建立成功的合作和慷慨的资源和数据共享的基础上。

The Udall Center for Excellence in Parkinson Disease Research at the Mayo Clinic is an integrated, multidisciplinary research program of neurologists, neuropsychologists, geneticists, neuropathologists and basic scientists in the study of the "Genetics and Molecular Biology of Parkinsonism." The Center draws upon the clinical strengths of the Mayo Clinic Movement Disorder Section and longitudinal studies of Parkinson disease (PD) and dementia with Lewy bodies (DLB) for the clinical material used in the research projects, as well as strong institutional commitment to PD research. The research proposed is highly synergistic despite the wide range of expertise and scientific background of the members of the Udall team. Each member of the team brings unique knowledge and skill sets to the mission, and together we are greater than the sum of the parts. The work proposed builds upon highly successful and productive cores that have been working together for over a decade. The clinical, genetic and pathologic resources are rivaled by few centers. The Mayo Udall Center is a unique complement to the Udall Center program. Success of our Udall Center has been based upon building successful collaborations and generous sharing of resources and data. This proposal has the overarching goal to better understand Lewy-related PD, which is the most common form of PD. Lewy bodies are also the hallmark of DLB and PD with dementia (PDD). How PDD and DLB relate to each other is unknown, but this non-motor complication of PD is of increasing interest to the Parkinson community. Strengths of our Udall Center are the large collection of multi-incident PD families, a proven track record of success in discovery of PD genes and a large collection of PD, PDD and DLB brains in a well annotated brain bank. The research proposal has three projects and five cores: Project 1. "Identification of genetic risk factors that predict disease onset, susceptibility and progression of PD," (PL: Matthew J. Farrer, PhD); Project 2. "Identification of candidate therapeutics for a-synuclein aggregation and cytotoxicity," (PL: Shu-Hui C. Yen, PhD); Project 3. "Molecular pathology of Lewy-related cognitive dysfunction," (PL: Dennis W. Dickson, MD); Core A. Administrative (CL: Dennis W. Dickson, MD); Core B. Clinical (CL: Zbigniew K. Wszolek, MD); Core C. Genetic (CL: Matthew J. Farrer PhD); Core D. Neuropathology (CL: Dennis W. Dickson MD) and Core E. Education and Outreach (CL: Ryan J. Uitti, MD).