FASEB SRC on From Causes to Consequences, to Treatment: Obesity in Perspective

描述（由申请人提供）：在美国的成年人口中，现在估计超过60%的人超重或肥胖，儿童肥胖症的患病率正以惊人的速度增加。卫生与公众服务部已将肥胖症列为21世纪最重大的公共卫生威胁/负担之一。迄今为止，预防和治疗肥胖的努力取得了好坏参半的成功，无疑反映了其起源和表达的潜在异质性。因此，考虑到影响体重调节、脂质沉积模式和脂肪组织功能的众多因素及其对代谢和疾病过程的影响， 肥胖研究领域寻求一个综合的观点，以更好地了解遗传，行为和外部环境之间错综复杂的相互作用，以确定最有效的治疗和预防途径。虽然有许多关于肥胖及其相关并发症的会议，但很少有人采取这种综合方法，以垂直整合的形式将这些主题聚集在一起。为了开发预防和治疗肥胖及其相关共病的有效方法，我们有责任了解肥胖发展的影响因素及其相互作用的各个方面。因此，拟议会议的目标是为研究肥胖症各个方面的研究人员提供一个机会，以互动和发起对话，努力鼓励从更综合的角度增加互动和合作。 说明：在美国的成年人口中，现在估计超过60%的人超重或肥胖，并且儿童肥胖症的患病率正在以惊人的速度增加。卫生与公众服务部已将肥胖症列为21世纪最重大的公共卫生威胁/负担之一。迄今为止，预防和治疗肥胖的努力取得了好坏参半的成功，无疑反映了其起源和表达的潜在异质性。因此，考虑到影响体重调节、脂质沉积模式和脂肪组织功能及其对代谢和疾病过程的影响的众多因素，肥胖研究领域寻求综合视角以更好地理解遗传、行为和外部环境之间错综复杂的相互作用以确定最有效的治疗和预防途径至关重要。虽然有许多关于肥胖及其相关并发症的会议，但很少有人采取这种综合方法，以垂直整合的形式将这些主题聚集在一起。为了开发预防和治疗肥胖及其相关共病的有效方法，我们有责任了解肥胖发展的影响因素及其相互作用的各个方面。因此，拟议会议的目标是为研究肥胖症各个方面的研究人员提供一个机会，以互动和发起对话，努力鼓励从更综合的角度增加互动和合作。

DESCRIPTION (provided by applicant): Among the adult population of the US it is now estimated that over 60 percent are overweight or obese, and the prevalence of childhood obesity is increasing at a staggering rate. The Department of Health and Human Services has ranked obesity among the most significant public health threats/burdens of the twenty-first century. To date efforts at prevention and treatment for obesity have met with mixed success, undoubtedly reflecting the underlying heterogeneity in its origin and expression. Therefore, given the multitude of factors impacting body weight regulation, patterns of lipid deposition, and adipose tissue function and their impact on metabolic and disease processes, it is critical for the field of obesity research to seek an integrative perspective in order to better understand the intricate interplay between genetics, behavior, and the external environment in order to identify the most productive avenues of treatment and prevention. While there are many conferences on obesity and its associated co-morbidities, few take such an integrative approach bringing together such topics in a vertically integrated format. In order to develop effective methods of prevention and treatment for obesity and its associated co-morbidities it is incumbent that we understand all aspects of the contributing factors, and their interactions, to the development of obesity. Therefore, the objective of the proposed conference is to provide an opportunity for researchers working on the various facets of obesity to interact and initiate a dialogue in an effort to encourage increased interaction and collaboration from a more integrated perspective. PROGRAM NARRATIVE: Among the adult population of the US it is now estimated that over 60 percent are overweight or obese, and the prevalence of childhood obesity is increasing at a staggering rate. The Department of Health and Human Services has ranked obesity among the most significant public health threats/burdens of the twenty-first century. To date efforts at prevention and treatment for obesity have met with mixed success, undoubtedly reflecting the underlying heterogeneity in its origin and expression. Therefore, given the multitude of factors impacting body weight regulation, patterns of lipid deposition, and adipose tissue function and their impact on metabolic and disease processes, it is critical for the field of obesity research t seek an integrative perspective in order to better understand the intricate interplay between genetics, behavior, and the external environment in order to identify the most productive avenues of treatment and prevention. While there are many conferences on obesity and its associated co-morbidities, few take such an integrative approach bringing together such topics in a vertically integrated format. In order to develop effective methods of prevention and treatment for obesity and its associated co-morbidities it is incumbent that we understand all aspects of the contributing factors, and their interactions, to the development of obesity. Therefore, the objective of the proposed conference is to provide an opportunity for researchers working on the various facets of obesity to interact and initiate a dialogue in an effort to encourage increased interaction and collaboration from a more integrated perspective.