Eunice Kennedy Shriver NICHD Cooperative Multicenter Neonatal Research Network

描述(由申请人提供)：杜克大学医学院新生儿学部热情地提交了这份续签申请，这是连续第三个周期参加尤尼斯·肯尼迪·施莱弗NlCHD赞助的合作多中心新生儿研究网络(NRN)。NRN的目的是对新生儿，特别是低出生体重或妊娠的新生儿进行干预性和观察性临床研究，以实现改善医学和神经发育结果的目标。我们在杜克大学的目标是：1)优先考虑和实施批准的NRN方案，同时保持90%的随访率；2)促进实习生的发展，并与来自多个学科的研究人员合作，推进新生儿护理；3)为NRN带来创新的尖端研究机会。为了支持这些目标，我们在2009年1月增加了北卡罗来纳大学教堂山分校(UNC)作为卫星站点。UNC的加入使研究人数翻了一番，并增强了我们的临床试验专业知识。我们是目前唯一参与所有三项NRN试点研究的NRN网站，并在2009年通用数据库中登记了3‘^最高数量的婴儿。我们维持多学科的随访诊所，临床试验的随访率为90%。我们参与了九个活跃的NRN小组委员会，并领导了两个主要的网络项目，这些项目结合了传染病、医学真菌学、生物医学工程和遗传流行病学方面的机构专业知识，即新生儿念珠菌病的早期诊断和NICHD NRN匿名DNA库。2010年，我们和来自5个NRN站点的研究人员使用DNA库完成了对极低出生体重儿常见发病率的全基因组扫描和7个候选基因分析。在上一个周期中，我们已经撰写或共同撰写了16本NRN出版物。我们优先考虑初级教员在NRN的参与，这从他们的概念和学习申请以及参与小组委员会得到了证明。在2010年的PAS上，来自杜克大学和其他两个NRN网站的年轻研究人员提出了对念珠菌病研究的二次分析。杜克大学和北卡罗来纳大学是临床和翻译科学奖(CTSA)网站。CTSA直接支持我们的NRN工作，并增加了进一步的创新机会。 公共卫生相关性(见说明)：新生儿研究网络的高影响力研究需要具有创新想法的活跃网站。杜克大学-北卡罗来纳大学的网站为网络研究提供了大量和多样化的患者群体，并增加了与网络合作者合作的非常强大的记录，以1)开发创新的、多学科的方法来解决新生儿的健康问题，以及2)促进年轻临床医生科学家的早期职业发展，他们将对新生儿的护理产生重大影响。

DESCRIPTION (provided by applicant): The Duke University School of Medicine, Division of Neonatology enthusiastically submits this renewal application for a third consecutive cycle of participation in the Eunice Kennedy Shriver NlCHD-sponsored Cooperative Multicenter Neonatal Research Network (NRN). The NRN's purpose is to perform interventional and observational clinical studies in newborn infants, particularly those of low birth weight or gestation, with the goal of achieving improved medical and neurodevelopmental outcomes. Our aims at Duke are to: 1) prioritize and conduct approved NRN protocols while maintaining a > 90% follow-up rate; 2) foster development of trainees and collaborations with investigators from multiple disciplines to advance the care of neonates; 3) bring innovative, cutting-edge research opportunities to the NRN. In support of these aims we added the University of North Carolina at Chapel Hill (UNC) as a satellite site in January 2009. The addition of UNC doubles the study population and enhances our clinical trial expertise. We are the only current NRN site participating in all three current NRN pilot studies, and enrolled the 3'^ highest number of infants in the 2009 Generic Data Base. We maintain multidisciplinary follow-up clinics with follow-up rates for clinical trials > 90%. We participate in nine active NRN subcommittees, and lead two major Network projects that combine institutional expertise in Infectious Diseases, Medical Mycology, Biomedical Engineering, and Genetic Epidemiology, namely, Early Diagnosis of Neonatal Candidiasis and the NICHD NRN Anonymized DNA Bank. In 2010 we and investigators from 5 NRN sites are using the DNA bank to complete a genome wide scan and 7 candidate gene analyses for common morbidities of extremely low birthweight infants. We have authored or co-authored 16 NRN publications in the last cycle. We prioritize involvement of junior faculty in the NRN as attested by their concept and study applications and participation in subcommittees. At PAS in 2010 young investigators from Duke and two other NRN sites presented secondary analyses of the Candidiasis study. Duke and UNC are Clinical and Translational Science Award (CTSA) sites. CTSA directly supports our NRN work and adds further opportunity for innovation. PUBLIC HEALTH RELEVANCE (See instructions): The Neonatal Research Network's high impact research requires active sites with innovative ideas. The Duke-UNC site provides a large and diverse patient population for Network studies and adds a very strong record of working with Network collaborators to 1) develop innovative, multidisciplinary approaches to health problems of newborn infants, and 2) foster early career development of young clinician scientists who will have significant impact on the care of newborns.