Malaria Parasite Ligands And Host Cell Receptors

本年度的成就： 1.我们继续寻找新的受体，通过全基因组分析可行的裂殖子。 2.研究了对AMA 1、RON 2和EBA-175的免疫应答。 这项工作通过鉴定受体和配体并确定这些靶点用于疫苗开发的潜力，继续扩大我们对寄生虫入侵红细胞的理解。 3.表观遗传学的研究，使用参与组蛋白修饰的恶性疟原虫基因的敲除。 4.非洲儿童严重疾病中PfEMP 1结构域的抗体 5.继续研究移动连接中分子的胞质结构域，以确定它们是否与醛缩酶或其他结合肌动蛋白的分子结合。在入侵过程中研究活的裂殖子以跟踪移动的连接。 6.阐明结形成的分子机制。 7.疟原虫在蚊子体内的发展。

Accomplishments during the year: 1. We continue the search for new receptors through genome-wide analysis of viable merozoites. 2. The immune response to AMA1, RON2 and EBA-175 has been studied. This work continues to expand our understanding of parasite invasion of red cells by identifying the receptors and ligands and determining the potential of these targets for vaccine development. 3. Study of epigenetics, using knockouts of P. falciparum genes involved in histone modification. 4. Antibodies to domains of PfEMP1 in severe disease in children in Africa. 5. Continue to study the cytoplasmic domains of molecules in the moving junction to determine if they bind to aldolase or other molecules that bind actin. Studying viable merozoites during invasion to follow the moving junction. 6. Elucidation of molecular mechanism of junction formation. 7. Plasmodium development in the mosquito.