NW Research Center for Excellence in Biodefense and Emerging Infectious Diseases

西北地区生物防御和新发传染病卓越中心（NWRCE）是全国生物医学研究计划网络的重要组成部分，旨在打击对人口的传染病威胁。NWRCE目前是一个高度互动的主题计划，专注于革兰氏阴性细菌病原体，自成立以来一直存在相同的一般一致的重点。有三个研究主题：（1）革兰氏阴性细菌致病机制，（2）对革兰氏阴性细菌病原体的先天免疫反应，以及（3）将（1）和（2）转化为早期治疗开发以预防或治疗革兰氏阴性细菌疾病。NWRCE的中心位于西雅图的华盛顿大学（UW）;在本次更新申请中，西雅图提出了多个研究中心，俄勒冈州提出了两个研究中心，爱达荷州提出了一个研究中心，马里兰州提出了一个研究中心。其他合作地点包括蒙大拿州的NIAID落基山实验室、维多利亚大学、不列颠哥伦比亚省，以及泰国、瑞典和墨西哥的合作者。项目、核心、国内和国际网站以及合作者都是高度互动的。在上一个资助期和NWRCE成立之前，提出这一建议的个人已经共同工作了多年。大多数新加入到这一申请中的研究人员都与该中心的成员有着长期的合作关系。NWRCE的互动性质和重点是该计划的主要优势，使NWRCE能够快速灵活地响应国家优先事项，以实现革兰氏阴性细菌感染方面的重要目标。

The Region X Northwest Regional Center of Excellence (NWRCE) for Biodefense and Emerging Infectious Diseases is an essential component in a nationwide network of biomedical research programs to combat infectious disease threats to the population. The NWRCE is currently a highly interactive and thematic program focused on Gram-negative bacterial pathogens, and the same general consistent focus has existed since its inception. There are three research themes: (1) mechanisms of Gram-negative bacterial pathogenesis, (2) innate immune responses to Gram-negative bacterial pathogens, and (3) translation of (1) and (2) into early stage therapeutic development to prevent or treat Gram-negative bacterial diseases. The NWRCE is centered at the University of Washington (UW) in Seattle; in this renewal application, multiple sites are proposed in Seattle, two in Oregon, one in Idaho, and one in Maryland. Additional sites for collaboration include the NIAID Rocky Mountain Laboratory in Montana, the University of Victoria, British Columbia, and collaborators at sites in Thailand, Sweden, and Mexico. The projects, cores, domestic and international sites, as well as collaborators, are highly interactive. The individuals that make up this proposal have worked together for many years during the last funding period and before the NWRCE was created. The majority of investigators newly added to this to this application for renewed funding of the NWRCE have had long collaborative relationships with members of the center. The interactive nature and focus of the NWRCE is a major strength of the program and allows the NWRCE to rapidly and nimbly respond to national priorities to achieve important objectives with respect to Gram-negative bacterial infections.