CTSA INFRASTRUCTURE FOR CLINICAL TRIALS

本分项目是CTSA供资的估计百分比，即 被用于广泛的研究领域(艾滋病研究、儿科研究或 临床试验)。列出的总成本仅是对CTSA金额的估计 用于这一研究领域的基础设施，而不是由 授予子项目或子项目工作人员的NCRR补助金。 描述(由申请者提供)：匹兹堡大学是唯一适合、致力于并有义务改变其学术文化、环境和结构的大学，以进一步推动临床和转化科学作为一门地方和国家的独特学科。该大学的临床和转化科学研究所(CTSI)成立于2006年，旨在领导一项史无前例的跨机构倡议，以实现这一目标。在过去的四年里，CTSI使大学的研究事业发生了革命性的变化，开发、培养和支持了一批训练有素的临床和转化型科学家，并使他们的创新研究得以实现。通过CTSA前项目的创新机构整合以及新的跨学科研究和培训计划的开发，CTSI使我们的科学家能够在生成新的生物医学知识并将这些知识双向转化到整个翻译研究领域方面出类拔萃。我们对CTSI的系统方法基于不断评估方案成果的演变转型过程，以过去和当前的活动为基础来创建新的和修改现有计划，并指导CTSI总体目标的演变。这种动态方法导致了十个CTSI核心中的无数基础设施、程序和服务的开发。它也是管理CTSI下一阶段演进增长的基础。在接下来的五年里，我们将：1)通过综合协作的方法来整合临床和转化性研究和教育项目，转变我们的机构；2)通过基于能力的教育计划和在各级培训中注入导师来转变我们的科学家，以通过下一代推动临床和转化性科学领域的发展；3)通过提供强大的资源环境来支持团队科学和通过开发数据共享机制来转变研究；4)通过参与性合作伙伴关系改变医疗实践和社区，允许全面的双向研究翻译。这些转变将导致匹兹堡大学的根本性变化，使CTSI的教职员工和研究人员能够进行有远见的、相关的临床和翻译研究。 公共卫生相关性(由申请者提供)：通过将临床和转化科学确立为一门不同的学科，CTSI的重点是将可操作的研究成果转化为实践和预防环境，改善个人和人口层面的健康。CTSI采用基于社区的参与式研究模式进行推广，使公民能够与CTSI合作，利用合理的公共卫生原则确定和解决他们自己的卫生保健需求。

This subproject represents an estimate of the percentage of the CTSA funding that is being utilized for a broad area of research (AIDS research, pediatric research, or clinical trials). The Total Cost listed is only an estimate of the amount of CTSA infrastructure going towards this area of research, not direct funding provided by the NCRR grant to the subproject or subproject staff. DESCRIPTION (provided by applicant): The University of Pittsburgh is uniquely suited, committed, and obligated to transform its academic culture, environment, and structure to further promote clinical and translational science as a distinct discipline locally and nationally. The University's Clinical and Translational Science Institute (CTSI) was founded in 2006 to lead an unprecedented inter-institutional initiative to achieve this goal. Over the past four years, CTSI revolutionized the University's research enterprise to develop, nurture, and support a new cadre of highly trained clinical and translational scientists and to enable their innovative research. Through novel institutional integration of pre-CTSA programs and the development of new interdisciplinary research and training initiatives, CTSI enabled our scientists to excel in generating new biomedical knowledge and translating this knowledge bidirectionally across the entire translational research spectrum. Our systematic approach to CTSI is based on an evolutionary transformation process that continuously evaluates programmatic outcomes, builds on past and current activities to create new and modify existing plans, and guides the evolution of CTSI's overarching goals. This dynamic approach resulted in the development of myriad infrastructure, programs, and services in ten CTSI Cores. It also serves as the basis for managing CTSI's next period of evolutionary growth. Over the next five years, we will: 1) transform our institution through an integrative collaborative approach to coalesce clinical and translational research and education programs, 2) transform our scientists through competency-based educational programs and the infusion of mentoring into all levels of training to advance the field of clinical and translational science through the next generation, 3) transform research by providing a robust resource environment to support team science and through the development of mechanisms for data sharing, and 4) transform health practice and the community through participatory partnerships that permit the full scope of bi-directional research translation. These transformations will lead to fundamental changes at the University of Pittsburgh that will enable CTSI faculty and investigators to conduct visionary, relevant clinical and translational research. PUBLIC HEALTH RELEVANCE (provided by applicant): By establishing clinical and translational science as a distinct discipline, CTSI's focus is on moving actionable research findings into practice and prevention settings, improving health at the individual and population levels. CTSI's outreach using a community based participatory research model enables citizens to partner with CTSI to identify and address their own health care needs using sound public health principles.