Pathology Core

病理学核心将在圣安东尼奥内森休克衰老中心发挥关键作用，因为病理学 随着年龄的增长呈指数增长，是与年龄有关的发病率和死亡率的主要原因。 与该中心将用于研究衰老的干预措施相关的病理学病变的知识是 对解释这些干预措施对衰老过程的影响至关重要。这些知识也将 深入了解干预措施的基本机制。老年人的病理学评价 当确定随着动物年龄的增长观察到的变化是否与 独立于潜在的病理条件。因此，必须准确和全面地 衰老动物的病理学评估。本文所述的病理学核心将建立在广泛的 圣安东尼奥研究人员的经验和核心负责人在啮齿动物病理学分析方面的专业知识。 病理学核心的具体目标如下： 1 2. 对已建立和新的癌症患者进行全面的临终和横断面病理分析， 啮齿动物模型，以及其他用于衰老研究的物种，在衰老的群体中自发死亡 保存在老化动物和寿命评估核心中。 对转基因啮齿类动物的组织/器官及其组织进行定量形态学分析， 通过3D和2D图像分析检查的对照同窝仔。 建立一个全面的组织病理学结果数据库，作为趋势分析的资源， 生物信息学人员，为新的研究提供基本的病理学信息，并开发 通过收集和存储组织样本来建立组织档案，以提供样本分析的资源 特别要求和新的形态学研究。 协助有兴趣进行老化基础生物动物研究的教职员及学生 病理学分析需要申请资助和准备手稿。

The Pathology Core will play a key role in the San Antonio Nathan Shock Aging Center because pathology increases exponentially with advancing age and is largely responsible for age-related morbidity and mortality. Knowledge of the pathological lesions associated with interventions that the Center will use to study aging is essential to interpreting the impact of these interventions on the aging process(es). This knowledge will also provide insight into the underlying mechanism(s) of the interventions. The pathological assessment of old animals is important when determining whether the changes observed as animals age are associated with or independent of underlying pathological conditions. It is, therefore, essential to obtain accurate and thorough pathological assessments of aging animals. The Pathology Core described herein will build on the extensive experience of researchers at San Antonio and the expertise of the Core Leader in rodent pathology analyses. The Specific Aims of the Pathology Core are as follows: 1 2. To conduct comprehensive end-of-life and cross-sectional pathological analyses of established and new rodent models, and other species used in aging research that die spontaneously in the aging colonies maintained in the Aging Animal and Longevity Assessment Core. To conduct quantitative morphometric analyses of the tissues/organs of transgenic rodents and their control littermates examined by the 3D and 2D image analyses. To develop a comprehensive database of histopathologic findings as a resource for trend analyses by bioinformatics personnel, to provide basic pathological information for new investigations, and to develop a tissue archive by collecting and storing tissue samples to provide a resource for the analysis of samples by special request and for new morphological research. To assist faculty and students who are interested in conducting basic biological animal research in aging with the pathological analyses needed for grant applications and manuscripts preparation.