PATHOLOGY CORE

病理学核心

• 批准号: 6946253
• 负责人: YUJI IKENO
• 金额: $ 10万
• 依托单位: UNIVERSITY OF TEXAS HLTH SCIENCE CENTER
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-07-01 至 2010-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6946253
• 关键词: biomedical facility; genetically modified animals; histopathology; immunocytochemistry; information systems; laboratory mouse; laboratory rat; longitudinal animal study; pathology; technology /technique development; tissue resource /registry

The Pathology Core will play a key role in the San Antonio Nathan Shock Aging Center because pathology increases exponentially with advancing age and is largely responsible for age-related morbidity and mortality. Knowledge of the pathological lesions associated with interventions that the Center will use to study aging is essential to interpreting the impact of these interventions on the aging process(es). This knowledge would also provide insight into the underlying mechanism(s) of the interventions. The pathological assessment of old animals is important when determining whether changes observed as animals age are associated with or independent of underlying pathological conditions. It is, therefore, essential to obtain accurate and thorough pathological assessments of aging animals. The Pathology Core described herein will build on the extensive experience of researchers at San Antonio and the expertise of the Core Leader in rodent pathology analyses. The Specific Aims of the Pathology Core are as follows: 1. To conduct comprehensive pathological analyses of established and new rodent models, and other species used in aging research that die spontaneously in the aging colonies maintained in the Animal Core. 2. To conduct cross-sectional pathological analyses of the transgenic rodents and their control littermates. 3. To conduct histological diagnosis and immunohistochemical analyses of the tissues/organs of transgenic rodents and their control littermates examined by the Proteomics/Oxidative Stress Core. 4. To develop a comprehensive database of histopathologic findings as a resource for trend analyses by bioinformatics personnel, and to provide basic pathological information for new investigations. 5. To develop a tissue bank by collecting and storing tissue samples to provide a resource for the analysis of samples by special request and for new morphological research. 6. To assist faculty and students who are interested in conducting basic biological animal research in aging with the pathological analyses needed for grant applications and manuscripts preparation.

病理学核心将在圣安东尼奥内森休克衰老中心发挥关键作用，因为 病理学随着年龄的增长呈指数增长，并且是与年龄相关的发病率和死亡率的主要原因。与干预措施相关的病理病变的知识，该中心将用于研究衰老是至关重要的解释这些干预措施对衰老过程的影响（ES）。这一知识还将有助于深入了解干预措施的基本机制。当确定随着动物年龄增长观察到的变化是否与基础病理学状况相关或独立时，老年动物的病理学评估非常重要。因此，对衰老动物进行准确和全面的病理学评估至关重要。本文所述的病理学核心将基于圣安东尼奥研究人员的丰富经验和啮齿动物病理学分析核心负责人的专业知识。病理学核心的具体目标如下：1。对已建立的和新的啮齿动物模型以及用于衰老研究的其他种属进行全面的病理学分析，这些种属在动物核心中保存的老化菌落中自发死亡。2.对转基因鼠及其同窝对照鼠进行横断面病理学分析。3.对蛋白质组学/氧化应激核心检测的转基因啮齿动物及其对照同窝仔的组织/器官进行组织学诊断和免疫组化分析。4.建立一个全面的组织病理学发现数据库，作为生物信息学人员进行趋势分析的资源，并为新的研究提供基本的病理学信息。5.通过收集和储存组织样本来建立组织库，为分析提供资源 样品的特殊要求和新的形态学研究。6.协助有兴趣进行老化基础生物动物研究的教职员及学生 病理学分析需要申请资助和准备手稿。