PATHOLOGY CORE

病理核心中心将在圣安东尼奥内森休克衰老中心发挥关键作用，因为 随着年龄的增长，病理学呈指数增长，并在很大程度上导致与年龄相关的发病率和死亡率。了解与该中心将用于研究衰老的干预措施相关的病理损害对于解释这些干预措施对衰老过程的影响至关重要。这一知识还将提供对干预的根本机制(S)的洞察。在确定随着动物年龄的增长观察到的变化是否与潜在的病理条件相关或独立时，对老年动物的病理评估是重要的。因此，对衰老动物进行准确和彻底的病理评估是至关重要的。这里描述的病理学核心将建立在圣安东尼奥研究人员的广泛经验和核心领导者在啮齿动物病理分析方面的专业知识的基础上。病理学核心的具体目标如下：1.对已建立的和新的啮齿动物模型，以及在动物核心维护的老化群体中自发死亡的其他物种进行全面的病理分析。2.对转基因鼠仔及其对照仔鼠进行横断面病理学分析。3.利用蛋白质组学/氧化应激核心技术对转基因鼠类及其对照仔鼠的组织器官进行组织学诊断和免疫组织化学分析。4.建立一个全面的组织病理学发现数据库，作为生物信息学人员进行趋势分析的资源，并为新的研究提供基本的病理学信息。5.建立组织资料库，收集和储存组织样本，为分析提供资源 样品的特殊要求和新的形态研究。6.协助有志从事衰老基础生物动物研究的师生 以及拨款申请和手稿准备所需的病理分析。

The Pathology Core will play a key role in the San Antonio Nathan Shock Aging Center because pathology increases exponentially with advancing age and is largely responsible for age-related morbidity and mortality. Knowledge of the pathological lesions associated with interventions that the Center will use to study aging is essential to interpreting the impact of these interventions on the aging process(es). This knowledge would also provide insight into the underlying mechanism(s) of the interventions. The pathological assessment of old animals is important when determining whether changes observed as animals age are associated with or independent of underlying pathological conditions. It is, therefore, essential to obtain accurate and thorough pathological assessments of aging animals. The Pathology Core described herein will build on the extensive experience of researchers at San Antonio and the expertise of the Core Leader in rodent pathology analyses. The Specific Aims of the Pathology Core are as follows: 1. To conduct comprehensive pathological analyses of established and new rodent models, and other species used in aging research that die spontaneously in the aging colonies maintained in the Animal Core. 2. To conduct cross-sectional pathological analyses of the transgenic rodents and their control littermates. 3. To conduct histological diagnosis and immunohistochemical analyses of the tissues/organs of transgenic rodents and their control littermates examined by the Proteomics/Oxidative Stress Core. 4. To develop a comprehensive database of histopathologic findings as a resource for trend analyses by bioinformatics personnel, and to provide basic pathological information for new investigations. 5. To develop a tissue bank by collecting and storing tissue samples to provide a resource for the analysis of samples by special request and for new morphological research. 6. To assist faculty and students who are interested in conducting basic biological animal research in aging with the pathological analyses needed for grant applications and manuscripts preparation.