PATHOLOGY

为了确定实验干预对衰老的影响，研究人员必须 了解干预如何改变随年龄增长而发生的病理病变。年龄相关病变 随着年龄的增长呈指数级增长，是与年龄有关的发病率的主要原因， mortality.病理学信息也为研究人员提供了潜在的洞察力， 干预的生物/分子机制。此外，老年人的病理评估 在生物衰老过程的基础研究中包括的动物是必要的，以帮助研究人员 确定所测量的生理/生化参数的变化是否与 与潜在的病理状况无关。因此，必须获得准确和全面的 衰老动物的病理学评估。病理学核心将提供三个领域的研究人员 项目详细的生命末期病理学分析的病变发生在殖民地的年龄 组织特异性（肝脏、骨骼肌和白色脂肪组织[WAT]）GHRKO小鼠。病理学核心 还将为四个项目的研究人员提供特定的横断面病理分析， 从艾姆斯侏儒、GHRKO和组织特异性GHRKO小鼠获得的组织。 病理学核心的具体目标如下： 目的1：对转基因小鼠及其野生型小鼠进行全面的病理学分析。 型自发死亡或在老化群体中处于濒死类别的同窝仔。 目的2：对从遗传学上获得的组织进行横断面组织病理学分析。 操纵小鼠及其同窝出生的小鼠。这些数据将使研究人员能够评估 在特定年龄对特定组织的组织学变化进行遗传操作。 相关性（参见说明）：

To determine the impact of an experimental intervention on aging, it is essential that an investigator have knowledge of how the intervention alters the pathological lesions that occur with age. Age-related pathology increases exponentially with advancing age and is largely responsible for age-related morbidity as well as mortality. Pathological information also provides investigators with insight into the potential biological/molecular mechanism(s) of the intervention. Furthermore, the pathological assessment of old animals that are included in basic studies of biological aging processes is necessary to help investigators determine whether the changes in physiological/biochemical parameters measured are associated with or are independent of underlying pathological conditions. Thus it is essential to obtain accurate and thorough pathological assessments of aging animals. The Pathology Core will provide investigators in the three Projects with detailed end-of-life pathological analyses of the lesions that occur with age in colonies of tissue-specific (liver, skeletal muscle and white adipose tissue [WAT]) GHRKO mice . The Pathology Core will also provide investigators in the four Projects with cross-sectional pathological analyses of the specific tissues obtained from Ames dwarf, GHRKO and tissue-specific GHRKO mice. The Specific Aims of the Pathology Core are as follows: Aim 1: To conduct comprehensive pathological analyses of the genetically manipulated mice and their wild- type littermates that die spontaneously or are in the moribund category in the aging colonies. Aim 2: To conduct cross-sectional histopathological analyses of tissues obtained from genetically manipulated mice and their littermates. These data will allow investigators to evaluate the effect of the genetic manipulations on the histological changes in specific tissues at specific age. RELEVANCE (See instructions):