Monitoring Outside the Home of Older Adults at Risk for Sudden Cardiac Death

描述（由申请人提供）：心脏性猝死（SCD）每年仅在美国就导致大约45万老年人死亡。大多数致命性SCD事件是由室性心律失常（室性心动过速和室性颤动）引起的，无论患者是否患有结构性心脏病。提出了一种个人动态心律失常监测和自动报警装置，用于美国数十万已知易死于心律失常的患者，但不被认为具有足够高的长期风险，可以使用植入式心律转复除颤器（ICD）进行预防性治疗。目前存在的室内心律失常监测和报警设备连接到固定电话和呼叫服务中心，以发起响应。不幸的是，对于在户外或车内行走的患者来说，目前还没有相应的设备，因为在这些地方，他们有可能出现未被发现的心脏骤停。提出的快速警报装置旨在供患者在户外使用，例如在锻炼或独自开车旅行时，自动检测心律失常事件，在本地发出警报，拨打911，并报告受害者的位置。

DESCRIPTION (provided by applicant): Sudden cardiac death (SCD) results in approximately 450,000 deaths each year in the United States alone of older adults. Most fatal SCD events are caused by ventricular arrhythmias (ventricular tachycardia and ventricular fibrillation) in patients both with and without identified structural heart disease. Proposed is a personal ambulatory arrhythmia monitoring and automated alerting device for the many hundreds of thousands of patients in the U.S. known to be susceptible to death from arrhythmia but not deemed at high enough long-term risk for prophylactic therapy with an implantable cardioverter-defibrillator (ICD). Indoor arrhythmia monitoring and alarming devices presently exist that are connected to a land-line phone and call service centers to initiate a response. Unfortunately there exists no equivalent device for patients walking outdoors or in a car where they are at risk for unwitnessed cardiac arrest. The proposed rapid alert device is intended for patient use out of the home, when exercising or travelling alone in a car for example, to automatically detect arrhythmia events, alert locally, call 911, and report a victim's location. PUBLIC HEALTH RELEVANCE: Sudden cardiac death (SCD) results in approximately 450,000 deaths each year in the United States and represents a health problem of epidemic proportions. Currently, beyond ten minutes after victim collapse, the likelihood of complete physical and neurologic recovery with conventional resuscitation is very low and overall survival for arrest victims is less than ten percent. This project proposes to develop wearable technology to automatically identify life-threatening cardiac arrhythmia, alarm locally, call 911, and report the victim's location to enable responders to provide defibrillation therapy as quickly as possible.